Clinicopathological differences and correlations between right and left colon cancer

查看全文 作　　者：Ioannis [1,2]Kalantzis;Afroditi [3]Nonni;Kitty [3]Pavlakis;Eumorphia-Maria [4]Delicha;Konstantinos [2,5]Miltiadou;Christos [2]Kosmas;Nikolaos [2]Ziras;Konstantinos [1]Gkoumas;Harikleia [3]Gakiopoulou

机构地区：[1]Department of Gastroenterology,Korgialenio-Mpenakeio Hellenic Red Cross Hospital,Athens 11526,Greece;[2]Department of Oncology,Metaxa Anticancer Hospital,Piraeus 18537,Greece;[3]First Department of Pathology,National and Kapodistrian University of Athens,Medical School,Athens 11527,Greece;[4]Independent Biostatistical Consultant,ASTAT,Statistics in Clinical Research,Glyfada 16675,Greece;[5]Hepatogastroenterology Unit,Second Department of Internal Medicine,Attikon University General Hospital,Athens 12462,Greece

出　　处：《World Journal of Clinical Cases》索引2020年第8卷第8期,共20页

摘　　要：BACKGROUND The differences in histopathology and molecular biology between right colon cancer(RCC)and left colon cancer(LCC)were first reported in the literature by Bufill in 1990.Since then,a large number of studies have confirmed their differences in epidemiology,clinical presentation,comorbidities and biological behaviours,which may be related to the difference in prognosis and overall survival(OS)between the two groups.AIM To investigate statistically significant differences between Greek patients with LCC and RCC.METHODS The present observational study included 144 patients diagnosed with colon cancer of any stage who received chemotherapy in a Greek tertiary oncology hospital during a 2.5-year period.Clinical information,comorbidities,histopathologic characteristics and molecular biomarkers were collected from the patients’medical records retrospectively,while administered chemotherapy regimens,targeted agents,progression-free survival(PFS)periods with first-and second-line chemotherapy and OS were recorded retroactively and prospectively.Data analysis was performed with the SPSS statistical package.RESULTS Eighty-six males and 58 females participated in the study.One hundred(69.4%)patients had a primary lesion in the left colon,and 44(30.6%)patients had a primary lesion in the right colon.Patients with RCC were more likely to display anaemia than patients with LCC[odds ratio(OR)=3.09],while LCC patients were more likely to develop rectal bleeding(OR=3.37)and a feeling of incomplete evacuation(OR=2.78)than RCC patients.Considering comorbidities,RCC patients were more likely to suffer from diabetes(OR=3.31)and coronary artery disease(P=0.056)than LCC patients.The mucinous differentiation rate was higher in the right-sided group than in the left-sided group(OR=4.49),as was the number of infiltrated lymph nodes(P=0.039),while the percentage of high-grade differentiation was higher in the group of patients with left-sided colon cancer than in RCC patients(OR=2.78).RAS wild-type patients who received anti-epidermal growth factor receptor(EGFR):Treatment experienced greater benefit(PFS:16.5 mo)than those who received anti-vascular endothelial growth factor treatment(PFS:13.7 mo)(P=0.05),while among RAS wild-type patients who received anti-EGFR treatment,LCC patients experienced greater benefit(PFS:15.8 mo)than the RCC subgroup(PFS:5.5 mo)in the first-line chemotherapy setting(P=0.034).BRAF-mutant patients had shorter PFS(9.3 mo)than BRAF wild-type patients(14.5 mo)(P=0.033).RCC patients showed a shorter tumour recurrence period(7.7 mo)than those with LCC(14.5 mo)(P<0.001),as well as shorter(OS)(58.4 mo for RCC patients;82.4 mo for LCC patients)(P=0.018).CONCLUSION RCC patients present more comorbidities,worse histological and molecular characteristics and a consequently higher probability of tumour recurrence,poor response to targeted therapy and shorter OS than LCC patients. 关键词：Colorectal neoplasm EPIDERMAL GROWTH FACTOR Vascular endothelial GROWTH FACTOR HISTOLOGY Molecular biology Metabolic syndrome

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Clinicopathological differences and correlations between right and left colon cancer

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