Molecular hydrogen:current knowledge on mechanism in alleviating free radical damage and diseases

查看全文 作　　者：Geru [1]Tao;Guohua [1]Song;Shucun [1]Qin

机构地区：[1]Key Laboratory of Atherosclerosis in University of Shandong,Institute of Atherosclerosis,Shandong First Medical University&Shandong Academy of Medical Sciences,Tai'an 271000,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2019年第51卷第12期,共9页

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.81770855);the Taishan Scholars Foundation of Shandong Province(No.ts201511057). 摘　　要：Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 200Z the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury,metabolic syndrome,inflammation,and cancer.All these pathological damages are concomitant with overproduction of reactive oxygen species(ROS)where molecular hydrogen has been widely demonstrated as a selective antioxidant.Although it is difficult to construe the molecular mechanism of hydrogen's biomedical effect,an increasing number of studies have been helping us draw the picture clearer with days passing by.In this review,we summarized the current knowledge on systemic and cellular modulation by hydrogen treatment.We discussed the antioxidative,anti-inflammatory,and anti-apoptosis effects of hydrogen,as well as its protection on mitochondria and the endoplasmic reticulum,regulation of intracellular signaling pathways,and balancing of the immune cell subtypes.We hope that this review will provide organized information that prompts further investigation for in?depth studies of hydrogen effect. 关键词：molecular hydrogen MECHANISM ANTIOXIDANT ANTI-INFLAMMATION ANTI-APOPTOSIS

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Molecular hydrogen:current knowledge on mechanism in alleviating free radical damage and diseases

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引证文献(20)

耦合文献(54)

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