The pathological role of ferroptosis in ischemia/reperfusion-related injury

查看全文 作　　者：Hong-Fa [1]Yan;Qing-Zhang [1]Tuo;Qiao-Zhi [2]Yin;Peng [1]Lei

机构地区：[1]Department of Neurology and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,and Collaborative Center for Biotherapy,Chengdu,Sichuan 610041,China;[2]Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610041,China

出　　处：《Zoological Research》索引2020年第41卷第3期,共11页

基　　金：the Ministry of Science and Technology of China(2018YFC1312300);National Natural Science Foundation of China(81722016,81801182);Sichuan Science and Technology Program(2018JPT0037,2018SZ0190);China Postdoctoral Science Foundation(2017M623041)。 摘　　要：Ischemia/reperfusion(I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore,we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury(IRI) associated cell damage and death. 关键词：ISCHEMIA/REPERFUSION Ferroptosis Reactive oxygen species Lipid peroxidation IRON

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The pathological role of ferroptosis in ischemia/reperfusion-related injury

参考文献(127)

引证文献(70)

耦合文献(222)

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