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GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

查看全文 作　　者：Amin [1,2]Zhang;Qian [1,2]Zhang;Gabriel [1,4]Alfranca;Shaojun [2,3]Pan;Zhicheng [1,2]Huang;Jin [1,2]Cheng;Qiang [5]Ma;Jie [1,2]Song;Yunxiang [1,2]Pan;Jian [1,2]Ni;Lijun [6]Ma;Daxiang [1,2,3]Cui 高影响力作者 机构地区：[1]Institute of Nano Biomedicine and Engineering,Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument,Department of Instrument Science and Engineering,School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,800 Dongchuan RD,Shanghai,200240,China;[2]National Center for Translational Medicine,Collaborative Innovational Center for System Biology,Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai,200240,China;[3]School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai,200240,China;[4]Instituto de Ciencia de Materiales de Aragón(ICMA),CSIC/Universidad de Zaragoza,C/Pedro Cerbuna 12,50009,Zaragoza,Spain;[5]Department of Tumor,Xintai People’s Hospital,Xintai,271200,China;[6]Department of Tumor in Tongren Hospital,Shanghai Jiao Tong University School of Medicine,1111 XianXia Road,Shanghai,200336,China高影响力机构 出　　处：《Nano Research》索引2020年第13卷第1期,共13页高影响力期刊 基　　金：support of the National Basic Research Program of China(Nos.2017YFA0205301 and 2015CB931802);the National Natural Scientific Foundation of China(Nos.81903169,81803094,81602184,81822024,and 81571729);Shanghai Municipal Commission of Economy and Information Technology Fund(No.XC-ZXSJ-02-2016-05);the Medical Engineering Cross Project of Shanghai Jiao Tong university(Nos.YG2016ZD10 and YG2017Z D05);the Project of Thousand Youth Talents from China,and the National Key Research and Development Program of China(No.2017YFC1200904);the financial support of Shanghai Sailing Program(No.19YF1422300);Sponsor from Startup Fund for Yongman Research at SJTU(No.18X100040044);Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument(No.15DZ2252000)are also acknowledged. 摘　　要：Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment.In this regard,we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic.The multifunctional probes consisted of a gold/platinum star-shaped core(Au/Pt star)conjugated with a GSH-sensitive disulfide bond(S–S),a targeting ligand(rHSA-FA),a near-infrared fluorophore(IR780)and glucose oxidase(GOx).When systemically administered in a xenografted murine model,the probes specifically targeted the tumor sites.As the disulfide linker was cleaved by intracellular GSH,the IR780 molecules could be released for photo-thermal therapy&photodynamic therapy(PTT&PDT)and imaging.Subsequently,the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system:GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity,and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic·OH for tumor oxidative damage.Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release,real-time imaging ability,and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features,which provides a potential strategy for effective tumor theragnostic. 关 键 词：Au/Pt star GSH-responsive GOx peroxidase sequential nanocatalyst cancer starving-like therapy enzyme oxidative therapy photo-thermal therapy&photodynamic therapy(PTT&PDT)
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