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A Whole-brain Map of Long-range Inputs to GABAergic Interneurons in the Mouse Caudal Forelimb Area

查看全文 作　　者：Zhuonan [1,2]Duan;Anan [1,2,3]Li;Hui [1,2,3]Gong;Xiangning [1,2,3]Li 高影响力作者 机构地区：[1]Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology,Wuhan 430074,China;[2]Ministry of Education Key Laboratory for Biomedical Photonics,School of Engineering Sciences,Huazhong University of Science and Technology,Wuhan 430074,China;[3]Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics,Suzhou 215125,China高影响力机构 出　　处：《Neuroscience Bulletin》索引2020年第36卷第5期,共13页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(61721092,91749209,and 31871088);the Director Fund of Wuhan National Laboratory for Optoelectronics。 摘　　要：The caudal forelimb area(CFA)of the mouse cortex is essential in many forelimb movements,and diverse types of GABAergic interneuron in the CFA are distinct in the mediation of cortical inhibition in motor information processing.However,their long-range inputs remain unclear.In the present study,we combined the monosynaptic rabies virus system with Cre driver mouse lines to generate a whole-brain map of the inputs to three major inhibitory interneuron types in the CFA.We discovered that each type was innervated by the same upstream areas,but there were quantitative differences in the inputs from the cortex,thalamus,and pallidum.Comparing the locations of the interneurons in two subregions of the CFA,we discovered that their long-range inputs were remarkably different in distribution and proportion.This whole-brain mapping indicates the existence of parallel pathway organization in the forelimb subnetwork and provides insight into the inhibitory processes in forelimb movement to reveal the structural architecture underlying the functions of the CFA. 关 键 词：Forelimb area Input circuit INTERNEURON PARVALBUMIN SOMATOSTATIN Vasoactive intestinal peptide
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