The Role of CARD9 in Metabolic Diseases

查看全文 作　　者：Cheng [1]TIAN;Ya-li [1]TUO;Yi [1]LU;Chuan-rui [1]XU;Ming [1]XIANG

机构地区：[1]Department of Pharmacology,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Current Medical Science》索引2020年第40卷第2期,共6页

基　　金：This study was supported by the National Natural Science Foundation of China(No.81872000). 摘　　要：Caspase recruitment domain containing protein 9(CARD9)is an adaptor protein that plays a critical role in pattern recognition receptors(PRRs)-mediated activation of NF-kB and mitogen-activated protein kinase(MAPK).This elicits initiation of the pro・inflammatory cytokines and leads to inflammatory responses,which has been recognized as a critical contributor to chronic inflammation.Current researches demonstrate that CARD9 is strongly associated with metabolic diseases,such as obesity,insulin resistance,atherosclerosis and so on.In this review,we summarize CARD9 signaling pathway and the role of CARD9 in metabolic diseases. 关键词：caspase recruitment domain containing protein 9 pattern recognition receptors metabolic diseases

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The Role of CARD9 in Metabolic Diseases

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