Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

查看全文 作　　者：Qi-qi [1]WANGI;Ming-xue [1]LI;Chen [1]LI;Xiao-xia [1]GU;Meng-zhu [2]ZHENG;Li-xia [1]CHEN;Hua [2]LI

机构地区：[1]Wuya College of Inovation,School of Pharmaceutical Engineering,Key Laboratory of Structure-Based Drug Design&Discovery,Ministry of Education,Shenyang Pharmaceutical Universiry,Shenyang 110016,China;[2]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Current Medical Science》索引2020年第40卷第2期,共13页

基　　金：This work was financially supported by grants from the National Natural Science Foundation of China(No.81773594,U1703111,81473254 and 81773637,31270399);Liaoning Revitalization Talents Program(No.XLYC1807182);Program for Liaoning Innovation Talents in University(No.LR2016002);Liaoning Province Natural Science Foundation(No.2019-MS-299);Shenyang Planning Project of Science and Technology(No.18-013-0-46). 摘　　要：In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared. 关键词：cancer energy metabolism cancer therapy natural products binding targets,inhibitors

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Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy

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