Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

查看全文 作　　者：Lin [1,2]Yuan;Jun-Bo [1,2]Zhao;Ying-Lei [1,2,3]Zhou;Ya-Bin [1,2,3]Qi;Qiong-Ya [1,2,3]Guo;Hai-Hui [1,2,3]Zhang;Muhammad Noman [1,2,3]Khan;Ling [1,2,3]Lan;Chang-He [1,2,3]Jia;Yan-Rui [1,2,3]Zhang;Song-Ze [1,2,3]Ding

机构地区：[1]Department of Gastroenterology and Hepatology,People's Hospital of Zhengzhou University,Henan Province,China;[2]Henan Provincial People’s Hospital,Henan Province,China;[3]Henan University School of Medicine,Zhengzhou 450003,Henan Province,China

出　　处：《World Journal of Gastroenterology》索引2020年第26卷第25期,共13页

基　　金：Supported by National Natural Science Foundation of China,No.U1604174;Henan Provincial Government-Health and Family Planning Commission,No.20170123;Henan Provincial Government-Health and Family Planning Commission Research Innovative Talents Project,No.51282;Henan Provincial Government-Science and Technology Bureau,No.142300410050. 摘　　要：BACKGROUND Type I Helicobacter pylori(H.pylori)infection causes severe gastric inflammation and is a predisposing factor for gastric carcinogenesis.However,its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated;it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17(G-17)and pepsinogens(PGs)during clinical practice.AIM To explore the prevalence of type I and type II H.pylori infection status and their impact on G-17 and PG levels in clinical practice.METHODS Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined,and 523 patients were enrolled in this study.H.pylori infection was confirmed by both 13C-urea breath test and serological assay.Patients were divided into non-atrophic gastritis(NAG),nonatrophic gastritis with erosion(NAGE),chronic atrophic gastritis(CAG),peptic ulcers(PU)and gastric cancer(GC)groups.Their serological G-17,PG I and PG II values and PG I/PG II ratio were also measured.RESULTS A total H.pylori infection rate of 3572 examined patients was 75.9%,the infection rate of 523 enrolled patients was 76.9%,among which type I H.pylori infection accounted for 72.4%(291/402)and type II was 27.6%;88.4%of GC patients were H.pylori positive,and 84.2%of them were type I infection,only 11.6%of GC patients were H.pylori negative.Infection rates of type I H.pylori in NAG,NAGE,CAG,PU and GC groups were 67.9%,62.7%,79.7%,77.6%and 84.2%,respectively.H.pylori infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II ratio.Both types of H.pylori induced higher G-17 level,but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG,NAGE and CAG groups over uninfected controls.Overall PG I levels showed no difference among all disease groups and in the presence or absence of H.pylori;in stratified analysis,its level was increased in GC and PU patients in H.pylori and type I H.pylori-positive groups.CONCLUSION Type I H.pylori infection is the major form of infection in this geographic region,and a very low percentage(11.6%)of GC patients are not infected by H.pylori.Both types of H.pylori induce an increase in G-17 level,while type I H.pylori is the major strain that affects PG I and PG IIs level and PG I/PG II ratio in stepwise chronic gastric disease.The data provide insights into H.pylori infection status and indicate the necessity and urgency for bacteria eradication and disease prevention in clinical practice. 关键词：Helicobacter pylori Chronic gastric diseases GASTRIN-17 PEPSINOGEN Gastric cancer

相关文献

参考文献（28）
引证文献（42）
耦合文献（17）

参考文献(28)

引证文献(42)

耦合文献(17)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

参考文献(28)

引证文献(42)

耦合文献(17)

用户提示