Structures of a P4-ATPase lipid flippase in lipid bilayers

查看全文 作　　者：Yilin [1,2]He;Jinkun [1]Xu;Xiaofei [1]Wu;Long [1]Li

机构地区：[1]State Key Laboratory of Membrane Biology,Peking-Tsinghua Center for Life Sciences,School of Life Sciences,Peking University,Beijing 100871,China;[2]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China

出　　处：《Protein & Cell》索引2020年第11卷第6期,共6页

摘　　要：Dear Editor,Phospholipid molecules are unevenly distributed in membrane bilayers of eukaryotic cells.Phosphatidylethanolamine(PE)and phosphatidylserine(PS)are concentrated in the cytoplasmic leaflet,whereas phosphatidylcholine(PC)is enriched in the exoplasmic leaflet(lumenal or extracellular leaflet)(van Meer et al.2008).Type 4 P-type ATPases(P4-ATPases)are the phospholipid flippases which move specific lipids from the exoplasmic leaflet to the cytoplasmic leaflet.P4-ATPases belong to the P-type ATPase family.P4-ATPases are conserved in eukaryotes. 关键词：enriched concentrated STRUCTURES

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Structures of a P4-ATPase lipid flippase in lipid bilayers

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