METTL4 is an snRNA m^6Am methyltransferase that regulates RNA splicing

查看全文 作　　者：Hao [1]Chen;Lei [1]Gu;Esteban [2]A.Orellana;Yuanyuan [3]Wang;Jiaojiao [4]Guo;Qi [2]Liu;Longfei [5,6]Wang;Zhangfei [1,5,6]Shen;Hao [5,6]Wu;Richard [2]I.Gregory;Yi [7,8]Xing;Yang [1]Shi

机构地区：[1]Division of Newborn Medicine and Program in Epigenetics,Boston Children's Hospital,Harvard Medical School,300 Longwood Avenue,Boston,MA 02115,USA;[2]Stem Cell Program,Division of Hematology/Oncology,Boston Children's Hospital,Deportment of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,MA 02115,USA;[3]Bioinformatics Interdepartmental Graduate Program,University of California,Los Angeles,Los Angeles,CA 90095,USA;[4]College of Science,Northeastern University,360 Huntington Ave.,Boston,MA 02115,USA;[5]Program in Cellular and Molecular Medicine,Boston Children's Hospital,Boston,MA 02115,USA;[6]Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,MA 02115,USA;[7]Center for Computational and Genomic Medicine,The Children’s Hospital of Philadelphia,Philodelphio,PA 19104,USA;[8]Department of Pathology and Laboratory Medicine,University of Pennsylvania,Philadelphia,PA 19104,USA

出　　处：《Cell Research》索引2020年第30卷第6期,共4页

基　　金：We thank Chunmei Li,Matthew Harris,Erdem Sendinc,and David Valle-Garcia for insightful advice.Y.S.is supported by BCH funds.R.I.G.is a recipient of the NCI Outstanding investigator Award(R35 CA232115-01);E.A.O.was supported by the Pew Latin American Fellows Program and by a Damon Runyon Fellowship(DRG-2378-19);Y.X.is supported by NIH grants(R01GM088342 and R01GM121827);Y.S.is an American Cancer Society Research Professor. 摘　　要：Dear Editor,Protein coding mRNAs and non-coding RNAs are extensively modifed by chemical modifications,'including methylation of the N^6position of adenosine(m^6A).^2While mRNA internal m^6A methylation is mediated by METTL3 and METTL14,which are members of the MT-A70 family,N^6-methylation of cap-adjacent No,2'-O-dimethyladenosine(m^6Am)is catalyzed by PCIF1.^3-6 Non-coding RNAs are also m^6Am methylated internally,7but the corresponding enzyme remains unknown.Here we provide evidence that METTL4 mediates internal m^6Am methylation of U2 small nuclear RNA(snRNA). 关键词：METHYLATION MODIFICATION METHYLTRANSFERASE

相关文献

参考文献（14）
引证文献（9）
耦合文献（0）

参考文献(14)

引证文献(9)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

METTL4 is an snRNA m^6Am methyltransferase that regulates RNA splicing

参考文献(14)

引证文献(9)

用户提示