Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers

查看全文 作　　者：Xiuliang [1,2]Cui;Yang [4]Liu;Wen [2]Sun;Jin [1,2]Ding;Xiaochen [3]Bo;Hongyang [1,2]Wang

机构地区：[1]National Center for Liver Cancer,Shanghai 201805,China;[2]International Cooperation Laboratory on Signal Transduction,Shanghai Eastern Hepatobiliary Surgery Hospital,Shanghai 200438,China;[3]Beijing Institute of Radiation Medicine,Beijing 100850,China;[4]Research Center for Clinical and Translational Medicine,Beijing 302 Hospital,Beijing 100039,China

出　　处：《Science China(Life Sciences)》索引2020年第63卷第8期,共12页

基　　金：supported by the National Natural Science Foundation of China(81602620,81700540 and 81770602);the State Key Project for Infectious Diseases(2015ZX09J15107);Shanghai Committee of Science and Technology(15431901600);Translational Application of Precision Medicine of Second Military Medical University(2017JZ52)。 摘　　要：microRNAs(miRNAs),particularly the exosomal miRNAs have been widely used as biomarkers and promising therapeutic targets in cancer.However,a comprehensive analysis of miRNA-gene regulatory network with clinical significance remains scarce.The emergence of high-throughput multi-omics data over large,well-characterized patient cohorts provides an unprecedented opportunity to address this problem.Herein,we performed a clinic-centered analysis to identify cancer-associated miRNAs,miRNA-target axis.We first calculated the correlation among miRNA,mRNA and 75 unique clinico-pathological characteristics(CPCs)in 26 cancer types,and established an online resource(4CR).Interestingly,we found that the high expression of several DNA methylation-related enzymes was associated with adverse outcomes of cancer patients,and these genes were regulated by a cluster of miRNAs.Furthermore,by integrating exosomal miRNA and m RNA databases,we identified exosomal miRNA biomarkers for non-invasive cancer surveillance and therapy monitoring.Finally,we explored the role of CPC-related miRNAs for therapeutic effect prediction of drugs based on their shared targets.Our analysis pipeline illustrated the significance of clinic-centered analysis in miRNA-gene pair identification and provided helpful clues for future cancer studies. 关键词：exosomal miRNA BIOMARKER clinical significance PROGNOSIS TCGA

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Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers

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