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Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study

查看全文 作　　者：Dan [1,5]Sun;Hui [2]Li;Xiao-Xia [4]Lu;Han [5]Xiao;Jie [3]Ren;Fu-Rong [3]Zhang;Zhi-Sheng [1]Liu 高影响力作者 机构地区：[1]Department of Neurology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China;[2]Department of Hematology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China;[3]Department of Intensive Care Unit,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China;[4]Department of Respiratory,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430015,China;[5]Institute of Maternal and Child Health,Wuhan Children's Hospital,Tongji Medical College,Huazhong University and Technology,Wuhan 430015,China高影响力机构 出　　处：《World Journal of Pediatrics》索引2020年第16卷第3期,共9页高影响力期刊 基　　金：We would like to thank the parents and children for participating in the study.We thank the doctors and nursing staff of Intensive Care Unit for their detailed assessments and dedicated care of these young patients. 摘　　要：Background An outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan,Hubei,China.People of all ages are susceptible to SARS-CoV-2 infection.No information on severe pediatric patients with COVID-19 has been reported.We aimed to describe the clinical features of severe pediatric patients with COVID-19.Methods We included eight severe or critically ill patients with COVID-19 who were treated at the Intensive Care Unit (ICU),Wuhan Children's Hospital from January 24 to February 24.We collected information including demographic data,symptoms,imaging data,laboratory findings,treatments and clinical outcomes of the patients with severe COVID-19.Results The onset age of the eight patients ranged from 2 months to 15 years;six were boys.The most common symptoms were polypnea (8/8),followed by fever (6/8) and cough (6/8).Chest imaging showed multiple patch-like shadows in seven patients and ground-glass opacity in six.Laboratory findings revealed normal or increased whole blood counts (7/8),increased C-reactive protein,procalcitonin and lactate dehydrogenase (6/8),and abnormal liver function (4/8).Other findings included decreased CD16 + CD56 (4/8) and Th/Ts*(1/8),increased CD3 (2/8),CD4 (4/8) and CD8 (1/8),IL-6 (2/8),IL-10 (5/8) and IFN-γ (2/8).Treatment modalities were focused on symptomatic and respiratory support.Two critically ill patients underwent invasive mechanical ventilation.Up to February 24,2020,three patients remained under treatment in ICU,the other five recovered and were discharged home.Conclusions In this series of severe pediatric patients in Wuhan,polypnea was the most common symptom,followed by fever and cough.Common imaging changes included multiple patch-like shadows and ground-glass opacity;and a cytokine storm was found in these patients,which appeared more serious in critically ill patients. 关 键 词：Children COVID-19 Novel coronavirus 2019-nCoV SEVERE Critical ill WUHAN
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