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Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

查看全文 作　　者：Jennifer L [1]Leiting;Jordan M [2]Cloyd;Ahmed [2]Ahmed;Keith [3]Fournier;Andrew J [3]Lee;Sophie [4]Dessureault;Seth [4]Felder;Jula [5]Veerapong;Joel M [5]Baumgartner;Callisia [6]Clarke;Harveshp [6]Mogal;Charles A [7]Staley;Mohammad Y [7]Zaidi;Sameer H [8]Patel;Syed A [8]Ahmad;Ryan J [9]Hendrix;Laura [10]Lambert;Daniel E [11]Abbott;Courtney [11]Pokrzywa;Mustafa [12]Raoof;Christopher J [12]LaRocca;Fabian M [13]Johnston;Jonathan [13]Greer;Travis E [1]Grotz 高影响力作者 机构地区：[1]Division of Hepatobiliary and Pancreas Surgery,Mayo Clinic,Rochester,MN 55901,United States;[2]Division of Surgical Oncology,Department of Surgery,The Ohio State University Wexner Medical Center,Columbus,OH 43210,United States;[3]Department of Surgical Oncology,University of Texas MD Anderson Cancer Center,Houston,TX 77030,United States;[4]Department of Gastrointestinal Oncology,Moffitt Cancer Center,Department of Oncologic Sciences,Morsani College of Medicine,Tampa,FL 33612,United States;[5]Division of Surgical Oncology,Department of Surgery,University of California,San Diego,CA 92093,United States;[6]Division of Surgical Oncology,Department of Surgery,Medical College of Wisconsin,Milwaukee,WI 53226,United States;[7]Division of Surgical Oncology,Winship Cancer Institute,Emory University,Atlanta,GA 30322,United States;[8]Department of Surgery,University of Cincinnati College of Medicine,Cincinnati,OH 45267,United States;[9]Division of Surgical Oncology,Department of Surgery,University of Massachusetts Medical School,Worcester,MA 01655,United States;[10]Peritoneal Surface Malignancy Program Section of Surgical Oncology,Huntsman Cancer Institute,University of Utah,Salt Lake City,UT 84112,United States;[11]Division of Surgical Oncology,Department of Surgery,University of Wisconsin,Madison,WI 53792,United States;[12]Christopher La Rocca,Division of Surgical Oncology,Department of Surgery,City of Hope National Medical Center,Duarte,CA 91010,United States;[13]Department of Surgery,Johns Hopkins University,Baltimore,MD 21287,United States高影响力机构 出　　处：《World Journal of Gastrointestinal Oncology》索引2020年第12卷第7期,共12页高影响力期刊 基　　金：the National Center for Advancing Translational Sciences;No.UL1TR002377。 摘　　要：BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal technique.AIM To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes.METHODS Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database.Post-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed HIPEC.RESULTS Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed HIPEC.There was no difference in re-operation or severe complications between the two groups.Closed HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d mortalities.On multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire cohort.These findings remained consistent in the appendiceal and the colorectal subgroups.CONCLUSION In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term outcomes.HIPEC technique may be left to the discretion of the operating surgeon. 关 键 词：Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional
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