Secondary causes of inflammatory bowel diseases

查看全文 作　　者：Yezaz A [1]Ghouri;Veysel [1]Tahan;Bo [2]Shen

机构地区：[1]Department of Internal Medicine,Division of Gastroenterology and Hepatology,University of Missouri-School of Medicine,Columbia,MO 65201,United States;[2]Department of Medicine and Surgery,Interventional IBD Center,Columbia University Irving Medical Center/New York Presbyterian Hospital,New York,NY 10032,United States

出　　处：《World Journal of Gastroenterology》索引2020年第26卷第28期,共20页

摘　　要：Inflammatory bowel diseases(IBD),conventionally consist of Crohn’s disease(CD)and ulcerative colitis.They occur in individuals with high risk genotype for the disease in the setting of appropriate environmental factors.The pathogenesis of IBD involves a dysregulated autoimmune response to gut dysbiosis,which in turn is triggered due to exposure to various inciting environmental factors.But there is no clearly defined etiology of IBD and this type of disease is termed as“idiopathic IBD”,“classic IBD”,or“primary IBD”.We reviewed the current medical literature and found that certain etiological factors may be responsible for the development of IBD or IBD-like conditions,and we consider this form of de novo IBD as“secondary IBD”.Currently known factors that are potentially responsible for giving rise to secondary IBD are medications;bowel altering surgeries and transplantation of organs,stem cells or fecal microbiome.Medications associated with the development of secondary IBD include;immunomodulators,anti-tumor necrosis factor alpha agents,anti-interleukin agents,interferons,immune stimulating agents and checkpoint inhibitors.Colectomy can in some cases give rise to de novo CD,pouchitis of the ileal pouch,or postcolectomy enteritis syndrome.After solid organ transplantation or hematopoietic stem cell transplantation,the recipient may develop de novo IBD or IBD flare.Fecal microbiota transplantation has been widely used to treat patients suffering from recurrent Clostridium difficile infection but can also causes IBD flares. 关键词：De novo inflammatory bowel disease Secondary inflammatory bowel disease Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Secondary causes of inflammatory bowel diseases

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