维普中文期刊产品整合服务

In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31

查看全文 作　　者：Jian [1]Wang;Lanyue [2]Cui;Yande [3]Ren;Yuhong [1]Zou;Jinlong [3]Ma;Chengjian [3]Wang;Zhongyin [1]Zheng;Xiaobo [4]Chen;Rongchang [2,5]Zeng;Yufeng [6]Zheng 高影响力作者 机构地区：[1]Department of Bioengineering,College of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao,266590,China;[2]Corrosion Laboratory for Light Metals,College of Materials Science and Engineering,Shandong University of Science and Technology,Qingdao,266590,China;[3]Affiliated Hospital of Medical College Qingdao University,Qingdao,266555,China;[4]School of Engineering,RM1T University,Carlton,3053,Victoria,Australia;[5]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou,450002,China;[6]State Key Laboratory for Turbulence and Complex Systems and Department of Materials Science and Engineering,College of Engineering,Peking University,Beijing,100871,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2020年第47卷第12期,共16页高影响力期刊 基　　金：financially supported by the National Nature Science Foundation of China(Nos.51571134 and 51601108);the Shandong University of Science and Technology Research Fund(No.2014TDJH104)。 摘　　要：The performance of biodegradable magnesium alloy requires special attention to rapid degradation and poor biocompatibility, which can cause the implant to fail. Here, a sodium montmorillonite(MMT)/bovine serum albumin(BSA) composite coating was prepared upon magnesium alloy AZ31 via hydrothermal synthesis, followed by dip coating. We evaluated the surface characterization and corrosion behavior in vitro, and the biocompatibility in vitro and in vivo. Biodegradation progress of the MMT-BSA coated Mg pieces was examined through hydrogen evolution, immersion tests, and electrochemical measurements in Hank’s solution. In vitro biocompatibility studies were evaluated via hemolysis tests, dynamic cruor time tests, platelet adhesion, MTT testing and live-dead stain of osteoblast cells(MC3 T3-E1). It was found that the MMT-BSA coating had good corrosion resistance and a marked improvement in biocompatibility in comparison to bare Mg alloy AZ31. in vivo studies were carried out in rat model and the degradation was characterized by computed tomography scans. Results revealed that the MMT-BSA coated Mg alloy AZ31 implants maintained their structural integrity and slight degradation after 120 d of post-implantation. A100% survival rate for the rats was observed with no obvious toxic damages on the organs and tissues.Additionally, we proposed a sound coating formation mechanism. Considering the good corrosion protection and biocompatibility, the MMT-BSA coated Mg alloy AZ31 is a promising candidate material for biomedical implants. 关 键 词：Magnesium alloy Hydrothermal synthesis Corrosion resistance BIOCOMPATIBILITY Coating
相关文献

参考文献(69)

引证文献(11)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费