COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

查看全文 作　　者：Ling [1,2]Xu;Dan-Dan [1,2]Yu;Yu-Hua [3]Ma;Yu-Lin [1,4]Yao;Rong-Hua [1,2]Luo;Xiao-Li [2]Feng;Hou-Rong [5]Cai;Jian-Bao [2]Han;Xue-Hui [1,4]Wang;Ming-Hua [2]Li;Chang-Wen [6]Ke;Yong-Tang [1,2,3]Zheng;Yong-Gang [1,3,4,7]Yao

机构地区：[1]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences,KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China;[2]Kunming National High-level Biosafety Research Center for Non-Human Primates,Center for Biosafety Mega-Science,Kunming Institute of Zoology,Chinese Academic of Sciences,Kunming,Yunnan 650107,China;[3]National Resource Center for Non-Human Primates,National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China;[4]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,China;[5]Department of Respiratory and Critical Care Medicine,the Affiliated Drum Tower Hospital of Nanjing University,Nanjing,Jiangsu 210008,China;[6]Medical Key Laboratory for Repository and Application of Pathogenic Microbiology,Guangdong Provincial Center for Disease Control and Prevention,Guangzhou,Guangdong 510440,China;[7]CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 2Q0Q3A,China

出　　处：《Zoological Research》索引2020年第41卷第5期,共10页

基　　金：partly supported by the National Key R&D Program of China(2020YFC0842000 to Y.T.Z.);National Natural Science Foundation of China(U1902215 to Y.G.Y.);National Science and Technology Major Projects of Infectious Disease Funds(2017ZX10304402 to Y.T.Z.);Yunnan Province(2018FB046 to D.D.Y.);CAS“Light of West China”Program(xbzg-zdsys-201909to Y.G.Y.and Y.T.Z.)。 摘　　要：Thecoronavirusdisease2019(COVID-19)pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here,different aged Chinese tree shrews(adult group, 1 year old;old group, 5–6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, laboratory, and histological analyses were performed on different days postinoculation(dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected animals. Viral RNA was consistently detected in lung tissues from infected animals at 3,5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase(AST) and blood urea nitrogen(BUN). Histological analysis of lung tissues from animals at 3 dpi(adult group) and 7 dpi(old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection. 关键词：SARS-CoV-2/HCoV-19 Treeshrews Animal model SUSCEPTIBILITY COVID-19

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COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

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