Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT

查看全文 作　　者：Wei [1]Shao;Chuang [1,2]Yang;Fangyuan [1]Li;Jiahe [1]Wu;Nan [1]Wang;Qiang [2]Ding;Jianqing [1]Gao;Daishun [1]Ling

机构地区：[1]Institute of Pharmaceutics and Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,Zhejiang,People’s Republic of China;[2]Jiangsu Breast Disease Center,The First Affiliated Hospital with Nanjing Medical University,Nanjing 210029,Jiangsu,People’s Republic of China

出　　处：《Nano-Micro Letters》索引2020年第12卷第11期,共14页

基　　金：the financial support provided by the National Key Research and Development Program of China(2016YFA0203600);the Natural Science Foundation of China(NSFC)Project(31822019,51703195,91859116,81430040,81571738);the One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province(2019C04024);the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(2018ZX09711002);the Zhejiang Provincial Natural Science Foundation of China(LGF19C100002);the Fundamental Research Funds for the Central Universities(2019XZZX00415,2020FZZX001-05);the Leading Talent of“Ten Thousand Plan”-National High-Level Talents Special Support Plan。 摘　　要：Simultaneous photothermal therapy(PTT)and photodynamic therapy(PDT)is beneficial for enhanced cancer therapy due to the synergistic effect.Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources.The emerging monocomponent diketopyrrolopyrrole(DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation,but suffer from low singlet oxygen quantum yield,which severely restricts the therapeutic efficacy.Herein,we report acceptor-oriented molecular design of a donor-acceptor-donor(D-A-D)conjugated small molecule(IID-ThTPA)-based phototheranostic agent,with isoindigo(IID)as selective acceptor and triphenylamine(TPA)as donor.The strong D-A strength and narrow singlet-triplet energy gap endow IID-ThTPA nanoparticles(IID-ThTPA NPs)high mass extinction coefficient(18.2 L g^-1 cm^-1),competitive photothermal conversion efficiency(35.4%),and a dramatically enhanced singlet oxygen quantum yield(84.0%)comparing with previously reported monocomponent PTT/PDT agents.Such a high PTT/PDT performance of IID-ThTPA NPs achieved superior tumor cooperative eradicating capability in vitro and in vivo. 关键词：Molecular design Isoindigo Conjugated small molecule nanoparticles Singlet-triplet energy gap Synergistic PTT/PDT

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Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT

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