Strategies for engineering advanced nanomedicines for gas therapy of cancer

查看全文 作　　者：Yingshuai [1]Wang;Tian [1]Yang;Qianjun [1]He

机构地区：[1]Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging,National-Regional Key Technology Engineering Laboratory for Medical Ultrasound,School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen 518060,China

出　　处：《National Science Review》索引2020年第7卷第9期,共28页

基　　金：This work was supported by the National Natural Science Foun-dation of China(51872188);the Shenzhen Basic Research Pro-gram(CYJ20170302151858466,JCYJ20170818093808351,JCYJ20170818141810756 and GJHZ20180418190532315);the Special Funds for the Development of Strategic Emerging IndustriesinShenzhen(20180309154519685);the PhD Start-up Fund of Natural Science Foundation of Guangdong Province(2017A030310471 and 2018A030310573);the China Postdoctoral Science Foundation(2018M643171)。 摘　　要：As an emerging and promising treatment method,gas therapy has attracted more and more attention for treatment of inflammation-related diseases,especially cancer.However,therapeutic/therapy-assisted gases(NO,CO,HgS,H2,O2,SO and CO2)and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release,resulting in limited cancer therapy efficacy and potential side effects.Therefore,development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired,and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also ced gas-releasingnanomedicines from four aspects:(1)stimuli-responsive strategies for controlled gas release;multi-model combination strategies based on gas therapy.Moreover,we highlight current issues and gaps in knowledge,and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer.This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.reduce their side effects.The design ofnanomedicines with these functions is vitally important,but challenging.In this review,we summarize a series of engineering strategies for construction of advar(2)catalytic strategies for controlled gas release;(3)tumor-targeted gas delivery strategies;(4) 关键词：NANOMEDICINE gas therapy drug delivery controlled release cancer treatment

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Strategies for engineering advanced nanomedicines for gas therapy of cancer

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