The expanded development and application of CRISPR system for sensitive nucleotide detection

查看全文 作　　者：Fengjing [1]Jia;Xuewen [4]Li;Chao [1]Zhang;Xueming [2,3]Tang

机构地区：[1]Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine,Shanghai East Hospital,Shanghai Key Laboratory of Signaling and Disease Research,School of Life Sciences and Technology,Tongji University,Shanghai 200000,China;[2]Institute of Biotechnology Research,Shanghai Academy of Agricultural Sciences,Key Laboratory of Agricultural Genetics and Breeding,Shanghai 201106,China;[3]Crops Ecological Environment Security Inspection and Supervision Center(Shanghai),Ministry of Agriculture and Rural Affairs,Shanghai 201106,China;[4]Silicon Gene Tech Co.,Ltd.,Shanghai 200124,China

出　　处：《Protein & Cell》索引2020年第11卷第9期,共6页

基　　金：The work was supported by grants from the National Key Research and Development Program of China(Grant No.2017YFA0103902);the National Natural Science Foundation of China(Grant No.31771283);the Fundamental Research Funds for the Central Universities of Tongji University(Grant No.22120190210);the SAAS Program for Excellent Research Team(Grant No.2017-B-07);the Shanghai Leading Talent Project(Grant No.2017067);the Shanghai Fresh Corn Technology System Project(Grant No.2017-10). 摘　　要：CRISPR/Cas system,originally developed as genetic editing tool,also shows great potentials for nucleotide detection.A recent study published in Molecular Cell(Freije et al.,2019)developed a Cas13a-based CARVER(Cas13-assisted restriction of viral expression and readout)to detect RNA viruses such as lymphocytic choriomeningitis,influenza A and vesicular stomatitis,which provided a potential expanded application for the detection of a broad range of viral nucleotides in disease diagnosis. 关键词：CRISPR/Cas expanded APPLICATION

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The expanded development and application of CRISPR system for sensitive nucleotide detection

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