Recent progress in the molecular imaging of therapeutic monoclonal antibodies

查看全文 作　　者：Kaifeng [1]He;Su [1]Zeng;Linghui [1]Qian

机构地区：[1]Institute of Drug Metabolism and Pharmaceutical Analysis,Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China

出　　处：《Journal of Pharmaceutical Analysis》索引2020年第10卷第5期,共17页

基　　金：We acknowledge financial support from the National Natural Science Foundation of China(81903574);the Fundamental Research Funds for the Central Universities(2019QNA7046,2020QNA7001). 摘　　要：Therapeutic monoclonal antibodies have become one of the central components of the healthcare system and continuous efforts are made to bring innovative antibody therapeutics to patients in need.It is equally critical to acquire sufficient knowledge of their molecular structure and biological functions to ensure the efficacy and safety by incorporating new detection approaches since new challenges like individual differences and resistance are presented.Conventional techniques for determining antibody disposition including plasma drug concentration measurements using LC-MS or ELISA,and tissue distribution using immunohistochemistry and immunofluorescence are now complemented with molecular imaging modalities like positron emission tomography and near-infrared fluorescence imaging to obtain more dynamic information,while methods for characterization of antibody’s interaction with the target antigen as well as visualization of its cellular and intercellular behavior are still under development.Recent progress in detecting therapeutic antibodies,in particular,the development of methods suitable for illustrating the molecular dynamics,is described here. 关键词：Therapeutic monoclonal antibodies Molecular structure Biological function Molecular imaging

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Recent progress in the molecular imaging of therapeutic monoclonal antibodies

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