New insights into the pathogenesis of Peyronie’s disease:A narrative review

查看全文 作　　者：Denis [1]V.Krakhotkin;Volodymyr [2]A.Chernylovskyi;Alexandre [3,4]Mottrie;Francesco [5]Greco;Ruslan [1]A.Bugaev

机构地区：[1]Outpatient Department,Central District Hospital,Kamenolomni,Rostov Region.Russia;[2]Department of Urology 1,City Clinical Hospital No-4,Dnipro,Ukraine;[3]Department of Urology,Onze Li eve Vrouw Hospital,Aalst,Belgium;[4]ORSI Academy,Me lie,Belgium;[5]Department of Urology,Humanitas Gcivazzeni,Bergamo,Italy

出　　处：《Chronic Diseases and Translational Medicine》索引2020年第6卷第3期,共17页

摘　　要：Peyronie’s disease(PD)is a benign,progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea(TA)of the penis.This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines,cell signaling pathways,biochemical mechanisms,genetic factors responsible for fibrogenesis.A growing body of literature has shown that PD is a chronically impaired,localized,wound healing process within the TA and the Smith space.It is caused by the influence of different pathological stimuli,most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features,imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase(MMP/TIMP),and suppressed antioxidant systems during chronic inflammation.Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling.The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators. 关键词：Peyronie’s disease Cell signal pathway Penile curvature MYOFIBROBLAST Extracellular matrix

相关文献

参考文献（144）
引证文献（0）
耦合文献（23）

参考文献(144)

耦合文献(23)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

New insights into the pathogenesis of Peyronie’s disease:A narrative review

参考文献(144)

耦合文献(23)

用户提示