维普中文期刊产品整合服务

P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration

查看全文 作　　者：Xu [1,2]Zhang;Ming [3]Zhu;Xiao-Liang [4]Jiang;Xing [4]Liu;Xue [4]Liu;Pan [2]Liu;Xian-Xian [1]Wu;Zhi-Wei [4]Yang;Tao [1,2]Qin 高影响力作者 机构地区：[1]Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450003,Henan Province,China;[2]Department of Hepato-Biliary-Pancreatic Surgery,Zhengzhou University People’s Hospital&Henan Provincial People’s Hospital,Zhengzhou 450003,Henan Province,China;[3]Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou 510000,Guangdong Province,China;[4]Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical Collage(PUMC),Beijing 100021,China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2020年第26卷第41期,共17页高影响力期刊 基　　金：Supported by National Natural Science Foundation of China,No. 81670387,No. 31671440,and No. 81800402。 摘　　要：BACKGROUND Acute pancreatitis(AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome(SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP.AIM To investigate the role and mechanism of PSGL-1 in the development of AP.METHODS The PSGL-1 expression on leukocytes was detected in peripheral blood of AP patients and volunteers. Pancreatic injury, inflammatory cytokines expression, and inflammatory cell infiltration was measured in AP mouse models induced with PSGL-1 knockout(PSGL-1-/-) and wild-type(PSGL-1+/+) mice. Leukocyteendothelial cell adhesion was measured in a peripheral blood mononuclear cell(PBMC)-endothelial cell coculture system.RESULTS The expression of PSGL-1 on monocytes and neutrophils was significantly increased in AP patients. Compared with PSGL-1+/+ mice, PSGL-1-/-AP mice induced by caerulein exhibited lower serum amylase, less Interleukin-1 beta(IL-1 beta) and Interleukin-6(IL-6) expression, less neutrophil and macrophage infiltration, and reduced peripheral neutrophil and monocyte accounts. PSGL-1 deficiency alleviated leukocyte-endothelial cell adhesion via IL-6 but not IL-1 beta.CONCLUSION PSGL-1 deficiency effectively inhibits the development of AP by preventing leukocyte-endothelial cell adhesion via IL-6 stimulation and may become a potential therapeutic target for treating AP. 关 键 词：P-selectin glycoprotein ligand 1 Acute pancreatitis INFLAMMATION Leukocyte adhesion INTERLEUKIN-6
相关文献

参考文献(34)

引证文献(9)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费