Oxidative stress and diabetes:antioxidative strategies

查看全文 作　　者：Pengju [1]Zhang;Tao [1]Li;Xingyun [1]Wu;Edouard [2]C.Nice;Canhua [1]Huang;Yuanyuan [1]Zhang

机构地区：[1]Department of Pharmacology,West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu 610041,China;[2]Department of Biochemistry and Molecular Biology,Monash University,Clayton,Victoria,Australia

出　　处：《Frontiers of Medicine》索引2020年第14卷第5期,共18页

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81770580,81430071,81821002,and 81790251);Sichuan Science and Technology Program(No.2018RZ0133). 摘　　要：Diabetes mellitus is one of the major public health problems worldwide.Considerable recent evidence suggests that the cellular reduction-oxidation(redox)imbalance leads to oxidative stress and subsequent occurrence and development of diabetes and related complications by regulating certain signaling pathways involved in p-cell dysfunction and insulin resistance.Reactive oxide species(ROS)can also directly oxidize certain proteins(defined as redox modification)involved in the diabetes process.There are a number of potential problems in the clinical application of antioxidant therapies including poor solubility,storage instability and nonselectivity of antioxidants.Novel antioxidant delivery systems may overcome pharmacokinetic and stability problem and improve the selectivity of scavenging ROS.We have therefore focused on the role of oxidative stress and antioxidative therapies in the pathogenesis of diabetes mellitus.Precise therapeutic interventions against ROS and downstream targets are now possible and provide important new insights into the treatment of diabetes. 关键词：DIABETES oxidative stress redox modification antioxidative therapy novel antioxidant delivery

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Oxidative stress and diabetes:antioxidative strategies

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