Therapeutic effects of dental pulp stem cells on vascular dementia in rat models

查看全文 作　　者：Xue-Mei [1]Zhang;Yang [1]Sun;Ying-Lian [1]Zhou;Zhuo-Min [1]Jiao;Dan [1]Yang;Yuan-Jiao [1]Ouyang;Mei-Yu [1]Yu;Jin-Yue [1]Li;Wei [1]Li;Duo [1]Wang;Hui [1]Yue;Jin [1]Fu

机构地区：[1]Department of Neurology,The 2nd Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang Province,China

出　　处：《Neural Regeneration Research》索引2021年第16卷第8期,共7页

基　　金：supported by Yu Weihan Fund for Distinguished Young Scholars of Harbin Medical University of China,No. 002000013 (to XMZ)。 摘　　要：Dental pulp stem cells are a type of adult stem cells with strong proliferative ability and multi-differentiation potential. There are no studies on treatment of vascular dementia with dental pulp stem cells. In the present study, rat models of vascular dementia were established by two-vessel occlusion, and 30 days later, rats were injected with 2 × 10^(7) dental pulp stem cells via the tail vein. At 70 days after vascular dementia induction, dental pulp stem cells had migrated to the brain tissue of rat vascular dementia models and differentiated into neuronlike cells. At the same time, doublecortin, neurofilament 200, and Neu N m RNA and protein expression levels in the brain tissue were increased, and glial fibrillary acidic protein m RNA and protein expression levels were decreased. Behavioral testing also revealed that dental pulp stem cell transplantation improved the cognitive function of rat vascular dementia models. These findings suggest that dental pulp stem cell transplantation is effective in treating vascular dementia possibly through a paracrine mechanism. The study was approved by the Animal Ethics Committee of Harbin Medical University(approval No. KY2017-132) in 2017. 关键词：animal model dental pulp stem cells PARACRINE REPAIR stem cells TRANSPLANTATION vascular dementia

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Therapeutic effects of dental pulp stem cells on vascular dementia in rat models

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