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Physico-chemical and biological evaluation of doxycycline loaded into hybrid oxide-polymer layer on Ti-Mo alloy

查看全文 作　　者：Alicja Kazek-[1,2]Kęsik;Agnieszka [1]Nosol;Joanna [1]Płonka;MonikaŚmiga-[3]Matuszowicz;Sebastian [2,4]Student;Monika Brzychczy-[5]Włoch;Małgorzata Krok-[6]Borkowicz;Elżbieta [6]Pamuła;Wojciech [1]Simka 高影响力作者 机构地区：[1]Faculty of Chemistry,Silesian University of Technology,B.Krzywoustego Street 6,44-100,Gliwice,Poland;[2]Biotechnology Centre,Silesian University of Technology,Krzywoustego 8 Street,44-100,Gliwice,Poland;[3]Faculty of Chemistry,Silesian University of Technology,M.Strzody 9 Street,44-100,Gliwice,Poland;[4]Department of Systems Biology and Engineering,Faculty of Automatic Control,Electronics and Computer Science,Silesian University of Technology,Akademicka 16 Street,44-100,Gliwice,Poland;[5]Department of Microbiology,Jagiellonian University Medical College,Czysta 18 Street,31-121,Krakow,Poland;[6]Faculty of Materials Science and Ceramics,AGH University of Science and Technology,Mickiewicza Av.30,30-059,Krakow,Poland高影响力机构 出　　处：《Bioactive Materials》索引2020年第5卷第3期,共11页高影响力期刊 基　　金：supported by the National Science Centre,Poland(UMO-2016/21/D/ST5/01652);supported by Rector’s Grant in the field of research and development(Silesian University of Technology,Poland,04/010/RGJ19/0095). 摘　　要：Oxide-polymer coatings were formed on the surface of the vanadium-free Ti–15Mo titanium alloy.The Ti alloy surface was modified by the plasma electrolytic oxidation process,and then,the polymer layer of a poly(D,Llactide-co-glycolide)with doxycycline was formed.The polymer evenly covered the porous oxide layer and filled some of the pores.However,the microstructure of the polymer surface was completely different from that of the PEO layer.The surface morphology,roughness and microstructure of the polymer layer were examined by scanning electron microscopy(SEM)and a confocal microscope.The results confirmed the effectiveness of polymer and doxycycline deposition in their stable chemical forms.The drug analysis was performed by highperformance liquid chromatography.The 1H NMR technique was used to monitor the course of hydrolytic degradation of PLGA.It was shown that the PLGA layer is hydrolysed within a few weeks,and the polyglycolidyl part of the copolymer is hydrolysed to glycolic acid as first and much faster than the polylactide one to lactic acid.This paper presents influence of different microstructures on the biological properties of modified titanium alloys.Cytocompatibility and bacterial adhesion tests were evaluated using osteoblast-like MG-63 cells and using the reference S.aureus and S.epidermidis strains.The results showed that the optimum concentration of doxycycline was found to inhibit the growth of the bacteria and that the layer is still cytocompatible. 关 键 词：BIOMATERIALS Titanium alloy Plasma electrolytic oxidation Oxide-polymer hybrid coatings DOXYCYCLINE
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