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Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium

查看全文 作　　者：Rui [1,18]Chen;Liping [2,18]Xie;Xiaobing [3,18]Cai;Yiran [4,18]Huang;Liqun [5,18]Zhou;Lulin [6,18]Ma;Xu [1,18]Gao;Chuanliang [1,18]Xu;Shancheng [1,18]Ren;Pengfei [7,18]Shao;Danfeng [8,18]Xu;Kexin [9,18]Xu;Zhangqun [10,18]Ye;Chunxiao [11,18]Liu;Dingwei [12,18]Ye;Li [13,18]Lu;Qiang [14,18]Fu;Jianquan [15,18]Hou;Jianlin [16,18]Yuan;Dalin [17,18]He;Tie [1,18]Zhou;Fubo [1,18]Wang;Biming [1,18]He;Yinghao [1,18]Sun 高影响力作者 机构地区：[1]Department of Urology,ShanghaiChanghai Hospital,Second Military Medical University,Shanghai,China;[2]Department of Urology,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China;[3]Department of Health Care,PLA Headquarters of the General Staff Guard Bureau,Beijing,China;[4]Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai,China;[5]Department of Urology,Peking University First Hospital,Institute of Urology,Peking University,National Urological Cancer Center,Beijing,China;[6]Department of Urology,Peking University Third Hospital,Beijing,China;[7]State Key Laboratory of Reproductive Medicine,Department of Urology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China;[8]Department of Urology,Shanghai Changzheng Hospital,Second Military Medical University,Shanghai,China;[9]Peking University People’s Hospital,Beijing,China;[10]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China;[11]Department of Urology,Zhujiang Hospital,Southern Medical University,Guangzhou,China;[12]Fudan University Shanghai Cancer Center and Department of Oncology,Shanghai,China;[13]Department of Urology,3rd Hospital of Sun Yat-Sen University,Guangzhou,China;[14]Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai,China;[15]The First Affiliated Hospital of Soochow University,Suzhou,China;[16]Department of Urology,Xijing Hospital,The Fourth Military Medical University,Xi’an,China;[17]Department ofUrology,First AffiliatedHospital ofMedical School,Xi’an JiaotongUniversity,Xi’an,China;[18]The Chinese Prostate Cancer Consortium高影响力机构 出　　处：《Asian Journal of Urology》索引2015年第2卷第2期,共7页高影响力期刊 摘　　要：Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. 关 键 词：Prostate cancer DIAGNOSIS Prostate-specific antigen Percent free PSA Chinese population ROC curve
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