Applications of circulating tumor cells for prostate cancer

查看全文 作　　者：Shirley [1]Cheng;Jie-Fu [1,2]Chen;Yi-Tsung [1,3]Lu;Leland [1,2,4]W.K.Chung;Hsian-Rong [5,6]Tseng;Edwin [1,2,7]M.Posadas

机构地区：[1]Urologic Oncology Program,Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center,Los Angeles,CA,USA;[2]Division of Hematology/Oncology,Department of Medicine,Cedars-Sinai Medical Center,Los Angeles,CA,USA;[3]Department of Internal Medicine,John H Stroger Hospital,Chicago,IL,USA;[4]Cancer Biology Program,Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center,Los Angeles,CA,USA;[5]California Nanosystems Institute,University of California,Los Angeles,CA,USA;[6]Department of Molecular Pharmacology,University of California,Los Angeles,CA,USA;[7]Translational Oncology Program,Samuel Oschin Comprehensive Cancer Institute,Cedars-Sinai Medical Center,Los Angeles,CA,USA

出　　处：《Asian Journal of Urology》索引2016年第3卷第4期,共6页

基　　金：The authors would like to extend thanks to the following organizations and groups for their continued support of CTC research efforts at the Samuel Oschin Comprehensive Cancer Institute:St.Anthony Fund for Prostate Cancer Discover,CD McKinnon Memorial Fund for Aggressive Variant Prostate Cancers,Michael&Trisha Berns Family Fund for Discovery,Steven Spielberg Family Prostate Cancer Discovery Fund,Prostate Cancer Research Program of the US Department of Defense(W81XWH-11-1-0422);Prostate Cancer Foundation,Alliance for Nanotechnology in Cancer(1U01CA198900-01);the National Cancer Institute. 摘　　要：One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression.Prostate cancer is among these diseases and greatly affects the health of men globally.Circulating tumor cells(CTCs)are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation.Not until recently,clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology.However,advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer.It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes,biochemical analyses,and genomic profiling.These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance.These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men. 关键词：Prostate cancer Circulating tumor cell BIOMARKER Liquid biopsy Molecular oncology

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Applications of circulating tumor cells for prostate cancer

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