The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma

查看全文 作　　者：Tian [1,2]Hu;Jincheng [3]Li;Chuhong [1]Zhang;Xiu [1]lv;Sai [1]Li;Sha [1]He;Hanxing [1]Yan;Yixi [1]Tan;Mingsheng [4]Lei;Meiling [1]Wen;Jianhong [1,2]Zuo

机构地区：[1]The Affiliated Nanhua Hospital,University of South China,Hengyang,Hunan,421001,China;[2]School of Medicine,University of South China,Hengyang,Hunan,421001,China;[3]Medical School,Shaoyang University,Shaoyang,Hunan,422000,China;[4]Department of Respiratory and Critical Care Medicine,Zhangjiajie City Hospital,Zhangjiajie,Hunan,427000,China

出　　处：《Genes & Diseases》索引2017年第4卷第2期,共7页

基　　金：National Nature Science Foundation of China,Grant number:81272960;Key Research Program from Science and Technology Department of Hunan Province China,Grant number:2013WK2010 and 2014SK2015;Key Research Program from Ministry of human Resources and Social Security of the People’s Republic of China,Grant number:(2016)176;The fund of Tianqing liver disease research,Grant number:(TQGB20140155). 摘　　要：The purpose of this study is to measure the expression of microRNA-4463 and microRNA-6087 between normal persons and patients with hepatocellular carcinoma(HCC),and to clarify the meaning of them in the prognosis evaluation in HCC.Forty-five samples from healthy people and patients,who had been diagnosed with hepatocellular carcinoma before any treatment,were collected to study respectively.Real-time PCR was used to detect the expression of miRNA-4463 and miRNA-6087 in the serum of control group and hepatocellular carcinoma patients.The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group(P<0.05),and the expression level was independent of gender,tumor size,cell types,stages,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and HBsAg status(P>0.05).But there was a significant difference of different level of AFP in HCC(P<0.05),and the difference between the group of AFP lower than 400 ug/l and the control group is statistically significant(P<0.05).Besides,the survival time had showed a significant difference at the high and low expression levels(P<0.05).But the expression level of miRNA-6087 was no difference in HCC and control group.The disorder of miRNA-4463 occurred in HCC,even the AFP level doesn’t rises.What’s more,patients who get the high level of miRNA-4463 seem to have a shorter survival time.And it contributes great to the prognostic evaluation.This is the first study to illustrate the potential significance of miRNA-4463 in the prognosis in HCC. 关键词：Hepatocellular carcinoma malignant tumors microRNA-4463 microRNA-6087 miR-4463 PROGNOSTIC

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The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma

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