Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

查看全文 作　　者：Mushtaq Ahmad [1]Ansari;Mohammad [2]Raish;Yousef A Bin [2]Jardan;Ajaz [3]Ahmad;Mudassar [2]Shahid;SheikhFayaz [1]Ahmad;Nazrul [2]Haq;Mohammad Rashid [1]Khan;Saleh A [1]Bakheet

机构地区：[1]Department of Pharmacology and Toxicology,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia;[2]Department of Pharmaceutics,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia;[3]Department of Clinical Pharmacy,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia

出　　处：《World Journal of Gastroenterology》索引2021年第27卷第7期,共17页

基　　金：Deanship of Scientific Research at King Saud University,No.RG-1439-083. 摘　　要：BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB. 关键词：Sinapic acid D-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis ANTIOXIDANT Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

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Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

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