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Mitochondria-targeted fluorescent probe based on vibration-induced emission for real-time monitoring mitophagy-specific viscosity dynamic

查看全文 作　　者：Shuangxi [1]Wang;Bicong [1]Zhou;Na [1]Wang;Changmin [1]Yu;Naidi [1]Yang;Jian [3]Chen;Qiong [1]Wu;Chengwu [1]Zhang;Lin [1]Li;Wei [1,2]Huang 高影响力作者 机构地区：[1]Key Laboratory of Flexible Electronics(KLOFE)&•Institute of Advanced Materials(1AM),Nanjing Tech University(NanjingTech),Nanjing 211800,China;[2]Shaanxi Institute of Flexible Electronics(SIFE),Northwestern Polytechnical University(NPU),Xi'an 710072,China;[3]Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers,Hunan University of Science and Technology,Xiangtan 411201,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2020年第31卷第11期,共6页高影响力期刊 基　　金：the National Natural Science Foundation of China(Nos.81672508 and 61601218);Key University Science Research Project of Jiangsu Province(No.19KJA520005);Jiangsu Provincial Foundation for Distinguished Young Scholars(No.BK20170041);Natural Science Basic Research Program of Shaanxi(No.2019JM-016);China-Sweden Joint Mobility Project(No.51811530018);Fundamental Research Funds for the Central Universities。 摘　　要：Directly monitoring mitophagy-specific viscosity dynamic in living cells is of great significance but remains challenging.Herein,this study reported a novel mitochondria-targeted fluorescent probe DPACDY based on vibration-induced emission(VIE)for monitoring viscosity changes during mitochondrial autophagy.This probe contained N,N’-diphenyl-dihydrodibenzo[a,c]phenazine(DPAC)as the VIE core and two positively charged pyridinium moieties for mitochondria anchoring.As the ambient viscosity increased,the vibration of DPAC-DY could be hindered,and subsequently resulting in the enhancement of fluorescence emission.In vitro and intracellular experiments indicated that the probe DPAC-DY showed highly sensitive response to viscosity due to VIE mechanism.Importantly,by virtue of this probe,in situ and real-time visualization of the specific viscosity dynamics during the mitochondrial autophagy process was achieved.Thus,this work provides a novel strategy for VIE-based viscosity response sensors applied to specific organelles and offers a platform for in-depth study of mitochondrial viscosity-related diseases. 关 键 词：Vibration-induced emission Autophagy VISCOSITY Fluorescence detection
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