Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization

查看全文 作　　者：Xiao [1,2,3,4]Liu;Yan [1,2,3,4]Su;Xueyan [1,2,3,4]Sun;Haixia [1,2,3,4]Fu;Qiusha [1,2,3,4]Huang;Qi [1,2,3,4]Chen;Xiaodong [1,2,3,4]Mo;Meng [1,2,3,4]Lv;Yuan [1,2,3,4]Kong;Lanping [1,2,3,4]Xu;Xiaojun [1,2,3,4]Huang;Xiaohui [1,2,3,4]Zhang

机构地区：[1]Peking University People’s Hospital,Beijing 100044,China;[2]Peking University Institute of Hematology,Beijing 100044,China;[3]National Clinical Research Center for Hematologic Disease,Beijing 100044,China;[4]Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China

出　　处：《Science China(Life Sciences)》索引2020年第63卷第11期,共11页

基　　金：supported by the National Key Research and Development Program of China (2017YFA0105500 and 2017YFA0105503);the Beijing Natural Science Foundation (H2018206423);the Key Program of the National Natural Science Foundation of China (81730004);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81621001);the National Natural Science Foundation of China (81670116);the Beijing Natural Science Foundation (7171013);he Beijing Municipal Science and Technology Commission (Z171100001017084)。 摘　　要：This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. Furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype. 关键词：ATO macrophage polarization acute graft-versus-host disease

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Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization

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