Self-reported Taste and Smell Disorders in Patients with COVID-19:Distinct Features in China

查看全文 作　　者：Jia [1]SONG;Yi-ke [1]DENG;Hai [1]WANG;Zhi-chao [1]WANG;Bo [1]LIAO;Jin [1]MA;Chao [1]HE;Li [1]PAN;Yang [1]LIU;Isam [2]Alobid;De-yun [3]WANG;Ming [1]ZENG;Joaquim [2]Mullol;Zheng [1]LIU

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;[2]Rhinology Unit and Smell Clinic,ENT Department,Hospital Clinic,IDIBAPS,Universitat de Barcelona,CIBERES,Barcelona 08036,Spain;[3]Department of Otolaryngology,Yong Loo Lin School of Medicine,National University of Singapore 699010,Singapore

出　　处：《Current Medical Science》索引2021年第41卷第1期,共10页

基　　金：the Natural Science Foundation of Hubei Province of China(No.2018CFB602);National Key R&D Program of China(No.2018YFC0116800);National Natural Science Foundation of China(Nos:81630024,81920108011,and 81900925)。 摘　　要：Last December 2019,a cluster of viral pneumonia cases identified as coronavirus disease 2019(COVID-19)was reported in Wuhan,China.We aimed to explore the frequencies of nasal symptoms in patients with COVID-19,including loss of smell and taste,as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19.In this retrospective study,1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital,Wuhan.Demographic data,laboratory values,comorbidities,symptoms,and numerical rating scale scores(0–10)of nasal symptoms were extracted from the hospital medical records,and confirmed or reevaluated by the telephone follow-up.From patients(n=1172)completing follow-up,199(17%)subjects had severe COVID-19 and 342(29.2%)reported nasal symptoms.20.6%COVID-19 patients had loss of taste(median score=6),while 11.4%had loss of smell(median score=5).Loss of taste scores,but not loss of smell scores,were significantly increased in severe vs.nonsevere COVID-19 patients.Interleukin(IL)-6 and lactose dehydrogenase(LDH)serum levels were positively correlated with loss of taste scores.About 80%of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks.In this cohort,only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19.Most patients recovered smell and taste dysfunctions in 2 weeks. 关键词：TASTE smell coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2

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Self-reported Taste and Smell Disorders in Patients with COVID-19:Distinct Features in China

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