Ganoderma lucidum spore oil(GLSO),a novel antioxidant,extends the average life span in Drosophila melanogaster

查看全文 作　　者：Yi [1,2,3]Zhang;Hongfei [3]Cai;Zhu [3]Tao;Cheng [3]Yuan;Zhaojian [3]Jiang;Juyan [2,3,4]Liu;Hiroshi [1,5]Kurihara;Wendong [2,3]Xu

机构地区：[1]Institute of Integrated Chinese and Western Medicine Postdoctoral Research Station,Jinan University,Guangzhou 510632,China;[2]Postdoctoral Research Station of Guangzhou Pharmaceutical Holdings Limited,Guangdong 510130,China;[3]Institute of National Engineering Research Center for Modernization of Extraction and Separation Process of Traditional Chinese Medicine,Hanfang Pharmaceutical Co.,Ltd,Guangdong 510240,China;[4]Guangzhou Pharmaceutical Holdings Ltd,Guangdong 510130,China;[5]Institute of Traditional Chinese Medicine and Natural Products,Jinan University,601,Huangpu Avenue West,Guangzhou,510632,China

出　　处：《Food Science and Human Wellness》索引2021年第10卷第1期,共7页

基　　金：the Science and Technology Department of Guangdong Province(No.2016B030302003);the Ministry of Science and Technology of China(No.2017YFC1703104). 摘　　要：In ancient China,Ganoderma lucidum was believed to be a medical fungus that could increase lifespan.Recently,pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds.However,the effects of spore oil isolated from Ganoderma lucidum remains unknown.In this study,the biological effects of Ganoderma lucidum spore oil(GLSO)were evaluated using a Drosophila melanogaster model.Compared with untreated groups,groups treated with GLSO had significantly longer average and maximum lifespan in both normal conditions and under oxidative stress.The activities of various antioxidant enzymes were measured to determine the antioxidant effect of GLSO.GLSO treatment markedly enhanced total superoxide dismutase(SOD)and catalase(CAT)activity and decreased levels of malondialdehyde(MDA).Further,we found dose-dependent increases in the mRNA expression of Cu,Zn-SOD,Mn-SOD,and CAT in GLSO-treated groups.These results suggest that GLSO may effectively eliminate free radicals and extend lifespan in Drosophila.Future work should investigate the value of GLSO as a functional food for the prevention of aging in larger animal models. 关键词：Ganoderma lucidum spore oil Antioxidant activity Drosophila melanogaster ANTI-AGING

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Ganoderma lucidum spore oil(GLSO),a novel antioxidant,extends the average life span in Drosophila melanogaster

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