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The association between folic acid supplementation,maternal folate during pregnancy and intelligence development in infants:a prospective cohort study

查看全文 作　　者：Shaokang [1]Wang;Jie [1]Wei;Di [1]Wang;Li [2]Hua;Da [1]Pan;Lingmeng [1]Fu;Jin [1]Yang;Guiju [1]Sun 高影响力作者 机构地区：[1]Key Laboratory of Environmental Medicine and Engineering of Ministry of Education,and Department of Nutrition and Food Hygiene,school of Public Health,Southeast University,Nanjing,China;[2]Jurong Maternity and Child Health Care Hospital,Zhenjiang,China高影响力机构 出　　处：《Food Science and Human Wellness》索引2021年第10卷第2期,共8页高影响力期刊 基　　金：the Nutrition Research Foundation of Chinese Nutrition Society---Research Fund of Feihe Physical Nutrition and Health(Grant No:CNS-Feihe2018B01);Nanjing medical science and technology development fund(Grant No:YKK19127). 摘　　要：Objective The study aimed to explore the association between folic acid supplementation,maternal nutritional levels during pregnancy and intelligence development of infants.Method This was a prospective cohort study,mothers and their offspring in Jurong Maternal and Child Health Hospital were followed up through pregnancy up to 1 year.The basic information of pregnant women was obtained through questionnaire survey,including pregnancy lifestyle,marital status,vitamin and mineral supplements during pregnancy.Blood samples of pregnant women were collected on admission,serum folate,vitamin B12 and homocysteine concentrations were determined.Maternal postpartum colostrum was collected and the concentrations of folate and vitamin B12 in colostrum were determined.Pregnant women(n=478)and their corresponding infants were followed up and the Developmental Screen Test scores were recorded at 1,3,6,8 and 12 months of age.Results Compared with the normal group,infants in the low serum folate group had a score of 0.12 points lower in the intellectual energy zone(95%CI:-0.23–-0.01,P=0.04),and infants with the high homocysteine level scored 1.30 points lower than the lower-level group(95%CI:-2.52–-0.08,P=0.04).In the colostrum low-vitamin B12 level group,infants scored 0.10 points lower(95%CI:-1.84–-0.02,P=0.02)in the social adaptation zone compared to the normal group.Conclusion In conclusion,folic acid supplementation in the pre-pregnancy supplementation group and the post-pregnancy supplementation group may be not associated with infant mental development.In addition,maternal folate and homocysteine may be related to the intellectual development of infants.The level of vitamin B_(12)in colostrum may be associated with infants’social adaptive capacity.This result may be caused by individual differences in folate and homocysteine metabolism in pregnant women. 关 键 词：Folic acid Vitamin B_(12) HOMOCYSTEINE Intelligent development
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