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Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells

查看全文 作　　者：Mingli [1,2]Zhu;Qin [2,3]Zou;Rongyao [2,3]Huang;Ying [1]Li;Xudong [2,3]Xing;Jianhuo [2,3]Fang;Liang [1]Ma;Lifei [2,3]Li;Xuerui [3]Yang;Li [1]Yu 高影响力作者 机构地区：[1]State Key Laboratory of Membrane Biology,Tsinghua University-Peking University Joint Center for Life Sciences,Beijing Frontier Research Center for Biological Structure,School of Life Science,Tsinghua University,Beijing 100084,China;[2]Joint Graduate Program of Peking-Tsinghuo-National Institute of Biological Science,Tsinghuo University,Beijing 100084,China;[3]MOE Key Laboratory of Bioinformatics,Tsinghuo University,Center for Synthetic&Systems Biology,Tsinghuo University,School of Life Science,Beijing 100084,China高影响力机构 出　　处：《Cell Research》索引2021年第31卷第2期,共4页高影响力期刊 基　　金：the Ministry of Science and Technology of China(2016YFA0500202 and 2017YFA0503404 to L.Y.and 2016YFC0906001 to X.Y.);the National Natural Science Foundation of China(31430053,31621063 and 31561143002 to L.Y.and 81972912 to X.Y.);the Independent Research of Tsinghua University(20161080135 to L.Y.and 2019Z06QCX01 to X.Y.). 摘　　要：Dear Editor,Migrasomes are recently discovered vesicular organelles which form on the retraction fibers(RFs)of migrating cells.'Once detached from cells,migrasomes can rupture and release their luminal contents'in a process named migracytosis.Recently,migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus,migracytosis is considered as a major mechanism for migrasomes to carry out their functions.It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,'and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.However,it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells. 关 键 词：RELEASING TRANSFER RUPTURE
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