Not only ACE2-the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19

查看全文 作　　者：loannis [1,2,3]Kyrou;Harpal [1,2,3]S.Randeva;Demetrios [4]A.Spandidos;Emmanouil [5]Karteris

机构地区：[1]Warwickshire Institute for the Study of Diabetes,Endocrinology and Metabolism(WISDEM),University Hospitals Coventry and Warwickshire NHS Trust,Coventry CV22DX,UK;[2]Aston Medical Research Institute,Aston Medical School,College of Health and Life Sciences,Aston University,Birmingham B47ET,UK;[3]Warwick Medical School,University of Warwick,Coventry G/47AL,UK;[4]Laboratory of Clinical Virology,Medical School,University of Crete,71409 Heraklion,Greece and 5Biosciences,College of Health,Medicine;[5]Life Sciences,Brunei University London,Uxbridge UB83PH,UK

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第2期,共3页

摘　　要：Two recently published studies published in Science by Daly et al.1 and Cantuti-Castelvetri et al.2 identified neuropilin-1(NRP1)as an additional cellular mediator which may facilitate the entry of the new severe acute respiratory syndrome(SARS)-coronavirus(CoV)-2(SARS-CoV-2)into host cells.The findings of these elegant studies collectively indicate that,in addition to the role of angiotensin-converting enzyme 2(ACE2)in mediating the cellular entry of SARS-CoV-2;NRP1 may act as a host cell mediator that can increase the infectivity and may thus contribute to the tissue/organ tropism of this coronavirus. 关键词：ACE2 al. acute

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Not only ACE2-the quest for additional host cell mediators of SARS-CoV-2 infection: Neuropilin-1 (NRP1) as a novel SARS-CoV-2 host cell entry mediator implicated in COVID-19

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