Functional hair follicle regeneration:an updated review

查看全文 作　　者：Shuaifei [1]Ji;Ziying [1]Zhu;Xiaoyan [1]Sun;Xiaobing [1]Fu

机构地区：[1]Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center,PLA General Hospital and PLA Medical College,PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury,Repair and Regeneration,Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,2019RU051,Beijing 100048,People's Republic of China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第3期,共11页

基　　金：supported,in part,by National Key Research and Development Plan(2018YFC1105704,2017YFC1103304,2016YFA0101000,2016YFA0101002);the National Nature Science Foundation of China(81871569,81830064,81721092);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059);the Military Medical Research and Development Projects(AWS17J005,2019-126). 摘　　要：The hair follicle(HF)is a highly conserved sensory organ associated with the immune response against pathogens,thermoregulation,sebum production,angiogenesis,neurogenesis and wound healing.Although recent advances in lineage-tracing techniques and the ability to profile gene expression in small populations of cells have increased the understanding of how stem cells operate during hair growth and regeneration,the construction of functional follicles with cycling activity is still a great challenge for the hair research field and for translational and clinical applications.Given that hair formation and cycling rely on tightly coordinated epithelial-mesenchymal interactions,we thus review potential cell sources with HF-inducive capacities and summarize current bioengineering strategies for HF regeneration with functional restoration. 关键词：HEALING WOUND HAIR

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Functional hair follicle regeneration:an updated review

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