Eosinophil-derived chemokine(hCCL 15/23,mCCL6)interacts with CCR1 to promote eosinophilic airway inflammation

查看全文 作　　者：Xufei [1]Du;Fei [1]Li;Chao [1,2]Zhang;Na [1]Li;Huaqiong [1]Huang;Zhehua [1]Shao;Min [1]Zhang;Xueqin [1]Zhan;Yicheng [1]He;Zhenyu [3]Ju;Wen [1]Li;Zhihua [1]Chen;Songmin [1,4,5]Ying;Huahao [1,6]Shen

机构地区：[1]Key Laboratory of Respiratory Disease of Zhejiang Province,Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;[2]Department of Anatomy,Zhejiang University School of Medicine,Hangzhou 310058,China;[3]Key Laboratory of Regenerative Medicine of Ministry of Education,Institute of Aging and Regenerative Medicine,Jinan University,Guangzhou,Guangdong 510632,China;[4]International Institutes of Medicine,Zhejiang University School of Medicine,Yiwu 322000,China;[5]Department of Pharmacology,Zhejiang University School of Medicine,Hangzhou 310058,China;[6]State Key Lab of Respiratory Disease,Guangzhou 510120,China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第3期,共11页

基　　金：supported by the National Natural Science Foundation of China(81930003,81420108001,81870007,81920108001);the Major Research Plan(91642202). 摘　　要：Eosinophils are terminally differentiated cells derived from hematopoietic stem cells(HSCs)in the bone marrow.Several studies have confirmed the effective roles of eosinophils in asthmatic airway pathogenesis.However,their regulatory functions have not been well elucidated.Here,increased C-C chemokine ligand 6(CCL6)in asthmatic mice and the human orthologs CCL15 and CCL23 that are highly expressed in asthma patients are described,which are mainly derived from eosinophils.Using Cc/6 knockout mice,further studies revealed CCL6-dependent allergic airway inflammation and committed eosinophilia in the bone marrow following ovalbumin(OVA)challenge and identified a CCL6-CCR1 regulatory axis in hematopoietic stem cells(HSCs).Eosinophil differentiation and airway inflammation were remarkably decreased by the specific CCR1 antagonist BX471.Thus,the study identifies that the CCL6-CCR1 axis is involved in the crosstalk between eosinophils and HSCs during the development of allergic airway inflammation,which also reveals a potential therapeutic strategy for targeting G protein-coupled receptors(GPCRs)for future clinical treatment of asthma. 关键词：CCR1 inflammation AIRWAY

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Eosinophil-derived chemokine(hCCL 15/23,mCCL6)interacts with CCR1 to promote eosinophilic airway inflammation

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