The interplay between dendritic cells and CD8 T lymphocytes is a crucial component of SARS-CoV-2 immunity

查看全文 作　　者：Jonas [1]Buttenschön;Jochen [2]Mattner 机构地区：[1]Mikrobiologisches Institut-Klinische Mikrobiologie,Immunologie und Hygiene,Universitätsklinikum Erlangen and Friedrich-Alexander Universität(FAU)Erlangen-Nürnberg,Erlangen,Germany;[2]Medical Immunology Campus Erlangen,FAU Erlangen-Nürnberg,Erlangen,Germany 出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第2期,共3页 基　　金：Open Access funding enabled and organized by Projekt DEAL。 摘　　要：SARS-CoV-2,a novel beta-coronavirus(CoV),causes the coronavirus disease 2019(COVID-19)pandemic,which manifests with a wide clinical spectrum ranging from asymptomatic carriage or mild disease to hospitalization and even death.The highly divergent and variable clinical outcomes,as well as the fluctuating involvement of different organ systems,link SARS-CoV-2 pathogenesis to the immune response of an individual host.Thus,detailed knowledge of the cellular and humoral mechanisms underlying antiviral immunity against SARS-CoV-2 is pivotal for understanding the concept of host susceptibility,evaluating therapeutic regimens and designing vaccination strategies.However,most studies so far have focused only on the analysis of immune responses in convalescent individuals.In contrast,Zhou and colleagues explored in detail different innate and adaptive immune cells in the peripheral blood of patients with acute disease in their latest report published in Immunity.Compared to convalescent individuals,they observed that acute SARS-CoV-2 infection quantitatively and qualitatively impairs dendritic cell(DC)and CD8 T-cell responses and interactions,despite rapid and abundant antibody production targeting dominant viral antigen epitopes. 关 键 词：IMMUNITY acute INVOLVEMENT