Immunological mechanisms and therapeutic targets of fatty liver diseases

查看全文 作　　者：Hua [1,2]Wang;Wajahat [3]Mehal;Laura [4,5,6]E.Nagy;Yaron [7]Rotman

机构地区：[1]Department of Oncology,the First Affiliated Hospital of Anhui Medical University,Hefei,Anhui,China;[2]InfIammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei,Anhui,China;[3]West Haven VA Medical Center,West Haven CT and Yale University School of Medicine,New Haven,CT,USA;[4]Department of Inflammation and Immunity,Cleveland Clinic,Cleveland,OH,USA;[5]Department of Gastroenterology and Hepatology,Center for Liver Disease Research,Cleveland Clinic,Cleveland,OH,USA;[6]Department of Molecular Medicine,Case Western Reserve University,Cleveland,OH,USA;[7]Liver and Energy Metabolism Section,Liver Diseases Branch,National Institute of Diabetes and Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD,USA

出　　处：《Cellular & Molecular Immunology》索引2021年第18卷第1期,共19页

基　　金：supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. 摘　　要：Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are the two major types of chronic liver disease worldwide.Inflammatory processes play key roles in the pathogeneses of fatty liver diseases,and continuous inflammation promotes the progression of alcoholic steatohepatitis(ASH)and nonalcoholic steatohepatitis(NASH).Although both ALD and NAFLD are closely related to inflammation,their respective developmental mechanisms differ to some extent.Here,we review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of ASH and NASH.Multiple cell types in the liver,including macrophages,neutrophils,other immune cell types and hepatocytes,are involved in fatty liver disease inflammation.In addition,microRNAs(miRNAs),extracellular vesicles(EVs),and complement also contribute to the inflammatory process,as does intertissue crosstalk between the liver and the intestine,adipose tissue,and the nervous system.We point out that inflammation also plays important roles in promoting liver repair and controlling bacterial infections.Understanding the complex regulatory process of disrupted homeostasis during the development of fatty liver diseases may lead to the development of improved targeted therapeutic intervention strategies. 关键词：ALD NAFLD INFLAMMATION CYTOKINE TARGET IMMUNE

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Immunological mechanisms and therapeutic targets of fatty liver diseases

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