Effect of extract from Yiyuan Yiliu Tang(益元抑瘤汤)on human lung adenocarcinoma and human hepatoma cell lines

查看全文 作　　者：Yl [1]Qingqing;CHANG [1]Qing;LIANG [1]Dongyu;CAI [2]Weiwei;QIU [2]Liying;YANG [3]Rong;JIANG [4]Guowei

机构地区：[1]Clinical Research Center,Jiading District Central Hospital Affiliated Shanghai University of Medicine&Health Sciences,Shanghai 201800,China;[2]Department of Basic Medicine,Wuxi Medical School,Jiangnan University,Wuxi 214122,China;[3]Pathology department Jiading District Central Hospital Affiliated Shanghai University of Medicine&Health Sciences,Shanghai 201800,China;[4]Departments of Pharmacy,Jiading District Central Hospital Affiliated Shanghai University of Medicine&Health Sciences,Shanghai 201800,China

出　　处：《Journal of Traditional Chinese Medicine》索引2021年第41卷第1期,共8页

基　　金：Supported by Institutional Funding(No.JDKW-2020-0013,the Nature Science Foundation of Jiading District,Shanghai;No.2020-ZD-03,the Key Projects of Jiading District Health Commission,Shanghai;No.JDKW-2018-W21,the Agricultural and Social Research Projects of Jiading,Shanghai;and No.2020-KY-14,the General project of Jiading District Health Commission,Shanghai)。 摘　　要：OBJECTIVE:To investigate the efficacy of the extract from Yiyuan Yiliu Tang(益元抑瘤汤,YYYLT)on human lung adenocarcinoma cells A549 and human hepatoma cells Bel7402.METHODS:The cancer cell lines were treated with various concentrations(0,100,200,300,and400μg/m L)of the crude water extract of YYYLT and then cell viability,toxicity,cytokine secretion,and cell cycle/apoptosis were determined by MTT assay,LDH assay,and flow cytometry,respectively.RESULTS:The extract from YYYLT significantly suppressed the proliferation of the cancer cell lines and the release of interleukin-2 and tumor necrosis factor-αin a dose-dependent manner.The extract also promoted apoptosis,caused cell cycle arrest at G0/G1 phase,and increased the expression of caspase-3,B-cell lymphoma-2(Bcl-2),and Bcl-2-associated X proteins.CONCLUSION:The extract from YYYLT might be a potential treatment for human lung and liver cancers. 关键词：Antineoplastic agents Cell cycle APOPTOSIS Nodal protein Yiyuan Yiliu Tang

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Effect of extract from Yiyuan Yiliu Tang(益元抑瘤汤)on human lung adenocarcinoma and human hepatoma cell lines

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