Isolation and identifi cation of antimicrobial metabolites from sea anemone-derived fungus Emericella sp.SMA01

查看全文 作　　者：Yang [1]YUE;Huahua [1,2]YU;Rongfeng [1,2]LI;Linfeng [3]HU;Song [1,2]LIU;Rong’e [1,2]XING;Pengcheng [1,2]LI

机构地区：[1]Key Laboratory of Experimental Marine Biology,Center for Ocean Mega-Science,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China;[2]Laboratory for Marine Drugs and Bioproducts,Pilot Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China;[3]School of Chemistry and Chemical Engineering,Henan Institute of Science and Technology,Xinxiang 453003,China

出　　处：《Journal of Oceanology and Limnology》索引2021年第39卷第3期,共10页

基　　金：Supported by the National Natural Science Foundation of China(Nos.41376004,41406152);the Key Research and Development Project of Shandong Province(No.2018GHY115008);the Youth Innovation Promotion Association of CAS,and the Scientific and Technological Innovation Project(No.2015ASKJ02)。 摘　　要：Marine symbiotic fungi represent an intriguing source of discovery of novel secondary metabolites with various biological activities.Sea anemones are benthic marine invertebrates,however,the cultivable symbiotic fungi residing in the sea anemones are paid few attentions compared to those derived from their cnidarian counterparts.Here we show the identification of antimicrobial secondary metabolites from the sea anemone-derived symbiotic fungi.Out offive isolated fungal strains,only the strain SMA01 showed strong antimicrobial activities,which was assigned into the genus Emericella based on the morphological characteristics and the ITS sequencing.Media swift from liquid fermentation to solid rice medium presented little influence on its antibacterial activity.A chemical investigation of the ethyl acetate extract of the Emericella sp.SMA01 led to discovery of the primary antibiotic metabolite phenazine-1-carboxylic acid.The IC_(50) values of the phenazine-1-carboxylic acid against Phytophthora capsici,Gibberella zeae,and Verticillium dahliae were determined to be 23.26-53.89μg/mL.To the best of our knowledge,this was the first report of Emericella sp.in sea anemones.The current study may benefit understanding of the defensive chemical interactions between the symbiotic fungi and their host sea anemones. 关键词：sea anemone symbiotic fungi phenazine-1-carboxylic acid antimicrobial activity

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Isolation and identifi cation of antimicrobial metabolites from sea anemone-derived fungus Emericella sp.SMA01

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