Newly synthesized M^(pro) inhibitors as potential oral anti-SARS-CoV-2 agents

查看全文 作　　者：Lin [1]Li;Shile [1,2,3]Huang 机构地区：[1]Department of Biochemistry and Molecular Biology,Louisiana State University Health Sciences Center,Shreveport,LA,USA;[2]Department of Hematology and Oncology,Louisiana State University Health Sciences Center,Shreveport,LA,USA;[3]Feist-Weiller Cancer Center,Louisiana State University Health Sciences Center,Shreveport,LA,USA 出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第4期,共2页 摘　　要：In a recent paper published in Science,Qiao et al.1 described the design,synthesis,and characterization of 32 new SARS-CoV-2 M^(pro) inhibitors.SARS-CoV-2 M^(pro) inhibitors have been reported,2 but there is no infection data in any animal models.For the first time,Qiao et al.1 demonstrated that oral or intraperitoneal treatment with two compounds(MI-09 and MI-30)exhibits effective antiviral activity in a SARS-CoV-2 infection transgenic mouse model. 关 键 词：synthesis POTENTIAL