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Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

查看全文 作　　者：Taejun [1]Yoon;Sung Soo [2]Ahn;Jung Yoon [2]Pyo;Jason Jungsik [2,3]Song;Yong-Beom [2,3]Park;Sang-Won [2,3]Lee 高影响力作者 机构地区：[1]Department of Medical Science,BK21 Plus Project,Yonsei University,College of Medicine,Seoul,Republic of Korea;[2]Division of Rheumatology,Department of Internal Medicine,Yonsei University College of Medicine,Seoul,Republic of Korea;[3]Institute for Immunology and Immunological Diseases,Yonsei University College of Medicine,Seoul,Republic of Korea高影响力机构 出　　处：《Chinese Medical Journal》索引2021年第10期,共7页高影响力期刊 基　　金：supported by a faculty research grant from the Yonsei University College of Medicine(No.6-2019-0184);a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,funded by the Ministry of Health and Welfare,Republic of Korea(No.HI14C1324)。 摘　　要：Background:Follistatin-like 1(FSTL1)plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes.We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis(AAV)-specific indices.Methods:We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with AAV.Clinical and laboratory data and AAV-specific indices were recorded.FSTL1 concentration was determined using the stored sera.The lowest tertile of the short-form 36-item health survey(SF-36)was defined as the current low SF-36.The cutoffs of serum FSTL1 for the current low SF-36 physical component summary(PCS)and SF-36 mental component summary(MCS)were extrapolated by the receiver operator characteristic curve.Results:The median age was 62.5 years(55.4%were women).Serum FSTL1 was significantly correlated with SF-36 PCS(r=-0.374),SF-36 MCS(r=-0.377),and C-reactive protein(CRP)(r=0.307),but not with Birmingham vasculitis activity score(BVAS).In the multivariable linear regression analyses,BVAS,CRP,and serum FSTL1 were independently associated with the current SF-36 PCS(β=-0.255,β=-0.430,andβ=-0.266,respectively)and the current SF-36 MCS(β=-0.234,β=-0.229,andβ=-0.296,respectively).Patients with serum FSTL1≥779.8 pg/mL and those with serum FSTL1≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without(relative risk 7.583 and 6.200,respectively).Conclusion:Serum FSTL1 could predict the current functional status in AAV patients. 关 键 词：Anti-neutrophil cytoplasmic antibody Follistatin-like 1 Functional status VASCULITIS
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