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Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I: C) for enhanced tumoral photodynamic-immunotherapy

查看全文 作　　者：Jun [1]Dai;Meng [1]Wu;Quan [2]Wang;Siyang [3]Ding;Xiaoqi [2]Dong;Liru [1]Xue;Qingqing [1]Zhu;Jian [4]Zhou;Fan [2]Xia;Shixuan [1]Wang;Yuning [3]Hong 高影响力作者 机构地区：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong Universily of Science and Technology,Wuhan 430032,China;[2]Engineering Research Center of Nano-Geomaterials of Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan 430074,China;[3]Department of Chemistry and Physics,La Trobe Institute for Molecular Science,La Trobe University,Melbourne,Victoria 3086,Australia;[4]College of Material,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou 311121,China高影响力机构 出　　处：《National Science Review》索引2021年第8卷第6期,共14页高影响力期刊 基　　金：This work was financially supported by the National Key R&D Program of China(2020YFA0211200);the National NaturalScience Foundation of China(21525523 and 21874121);Australian Research Council(DE170100058);Australia China Science and Research Fund-Joint Research Centre on Personal Health Technologies。 摘　　要：Red blood cell(RBC)-mimicking nanoparticles(NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design and preparation of RBC membrane-bound NPs(M@AP), for tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly of the positively charged aggregation-induced emission luminogen(AIEgen)(named P2-PPh3) and the negatively charged polyinosinic : polycytidylic acid(Poly(I : C)), followed by RBC membrane encapsulation. P2-PPh3 is an AIE-active conjugated polyelectrolyte with additional photosensitizing ability for photodynamic therapy(PDT), while Poly(I : C) serves as an immune-stimulant to stimulate both tumor and immune cells to activate immunity, and thus reduces tumor cell viability. When applied in tumor-bearing mice, the M@AP NPs are enriched in both the tumor region as a result of an enhanced permeability and retention(EPR)effect, and the spleen because of the homing effect of the RBC-mimicking shell. Upon light irradiation,P2-PPh3 promotes strong ROS generation in tumor cells, inducing the release of tumor antigens(TA). The anti-tumor immunity is further enhanced by the presence of Poly(I : C) in M@AP. Thus, this strategy combines the PDT properties of the AIE-active polyelectrolyte and immunotherapy properties of Poly(I : C) to achieve synergistic activation of the immune system for anti-tumor activity, providing a novel strategy for tumor treatment. 关 键 词：biomimetic drug delivery system aggregation-induced emission Poly(I:C) IMMUNOTHERAPY photodynamic therapy
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