Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

查看全文 作　　者：Jun [1,2,3]Wan;Hongji [4]Dai;Xiaoli [5,6]Zhang;Sheng [1,2]Liu;Yuan [7]Lin;Ally-Khan [8]Somani;Jingwu [5,6]Xie;Jiali [6,7]Han

机构地区：[1]Department of Medical and Molecular Genetics,Indiana University School of Medicine,Indianapolis,IN,46202,USA;[2]Center for Computational Biology and Bioinformatics,Indiana University School of Medicine,Indianapolis,IN,46202,USA;[3]School of Informatics and Computing,Indiana University e Purdue University at Indianapolis,Indianapolis,IN,46202,USA;[4]Department of Epidemiology and Biostatistics,Key Laboratory of Cancer Prevention and Therapy,National Clinical Research Center of Cancer,Tianjin Medical University Cancer Institute and Hospital,Tianjin,300000,PR China;[5]Wells Center for Pediatric Research,Department of Pediatrics,Indiana University School of Medicine,Indianapolis,IN,46202,USA;[6]Melvin and Bren Simon Cancer Center,Indiana University School of Medicine,Indianapolis,IN,46202,USA;[7]Department of Epidemiology,Richard M.Fairbanks School of Public Health,Indiana University,Indianapolis,IN,46202,USA;[8]Dermatologic Surgery&Cutaneous Oncology Division,Department of Dermatology,Indiana University School of Medicine,Indianapolis,IN,46202,USA

出　　处：《Genes & Diseases》索引2021年第8卷第2期,共12页

基　　金：This research is generously supported by Riley Children’s Foundation(J.X.)and AGA Foundation(J.X.).We acknowledge support from the IU Simon Cancer Center(grant number P30CA082709),the Purdue University Center for Cancer Research(grant number P30CA023168),and the Walther Cancer Foundation. 摘　　要：The majority of non-melanoma skin cancer(NMSC)is cutaneous basal cell carcinoma(BCC)or squamous cell carcinoma(SCC),which are also called keratinocyte carcinomas,as both of them originate from keratinocytes.The incidence of keratinocyte carcinomas is over 5 million per year in the US,three-fold higher than the total incidence of all other types of cancer combined.While there are several reports on gene expression profiling of BCC and SCC,there are significant variations in the reported gene expression changes in different studies.One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls.Furthermore,while numerous studies of skin stem cells in mouse models have been reported,their relevance to human skin cancer remains unknown.In this report,we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control.Among several novel findings,we discovered a significant number of zinc finger encoding genes up-regulated in human BCC.In BCC,a novel link was found between hedgehog signaling,Wnt signaling,and the cilium.While the SCC cancerstem-cell gene signature is shared between human and mouse SCCs,the hair follicle stem-cell signature of mice was not highly represented in human SCC.Differential gene expression(DEG)in human BCC shares gene signature with both bulge and epidermal stem cells.We have also determined that human BCCs and SCCs have distinct gene expression patterns,and some of them are not fully reflected in current mouse models. 关键词：Basal cell carcinoma GLI1 Hedgehog signaling PTCH1 Squamous cell carcinoma

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Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

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