Bioinspired mineralized collagen scaffolds for bone tissue engineering

查看全文 作　　者：Zhengwei [1,2]Li;Tianming [1]Du;Changshun [2]Ruan;Xufeng [1,3,4]Niu

机构地区：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,PR China;[2]Research Center for Human Tissue and Organs Degeneration,Institute of Biomedicine and Biotechnology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,PR China;[3]Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing,100083,PR China;[4]Research Institute of Beihang University in Shenzhen,Shenzhen,518057,PR China

出　　处：《Bioactive Materials》索引2021年第6卷第5期,共21页

基　　金：the support for this work from the National Key Research and Development Program of China[Grant No.2018YFA0703100];the National Natural Science Foundation of China[Grant Nos.11872097,82072082];the Youth Innovation Promotion Association of CAS[Grant No.2019350];Beijing Natural Science Foundation[No.L182017];the 111 Project[No.B13003]and the Shenzhen Fundamental Research Foundation[Grant No.JCYJ20180507182237428]. 摘　　要：Successful regeneration of large segmental bone defects remains a major challenge in clinical orthopedics,thus it is of important significance to fabricate a suitable alternative material to stimulate bone regeneration.Due to their excellent biocompatibility,sufficient mechanical strength,and similar structure and composition of natural bone,the mineralized collagen scaffolds(MCSs)have been increasingly used as bone substitutes via tissue engineering approaches.Herein,we thoroughly summarize the state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair,including their fabrication methods,critical factors for osteogenesis regulation,current opportunities and challenges in the future.First,the current fabrication methods for MCSs,mainly including direct mineral composite,in-situ mineralization and 3D printing techniques,have been proposed to improve their biomimetic physical structures in this review.Meanwhile,three aspects of physical(mechanics and morphology),biological(cells and growth factors)and chemical(composition and cross-linking)cues are described as the critical factors for regulating the osteogenic feature of MCSs.Finally,the opportunities and challenges associated with MCSs as bone tissue-engineered scaffolds are also discussed to point out the future directions for building the next generation of MCSs that should be endowed with satisfactorily mimetic structures and appropriately biological characters for bone regeneration. 关键词：COLLAGEN MINERALIZATION SCAFFOLD Bone repair 3D printing BIOMECHANICS

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Bioinspired mineralized collagen scaffolds for bone tissue engineering

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