维普中文期刊产品整合服务

Development of a polycaprolactone/poly(p-dioxanone)bioresorbable stent with mechanically self-reinforced structure for congenital heart disease treatment

查看全文 作　　者：Fan [1,2,4]Zhao;Jing [3]Sun;Wen [1,2]Xue;Fujun [1,2]Wang;Martin [4]W.King;Chenglong [1,2]Yu;Yongjie [1,2]Jiao;Kun [3]Sun;Lu [1,2]Wang 高影响力作者 机构地区：[1]College of Textiles,Donghua University,Shanghai,201620,China;[2]Key Laboratory of Textile Science and Technology,Ministry of Education,College of Textiles,Donghua University,Songjiang District,Shanghai,201620,China;[3]Department of Pediatric Cardiology,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,No.1665 Kongjiang Road,Shanghai,200092,China;[4]Wilson College of Textiles,North Carolina State University,Raleigh,27606,USA高影响力机构 出　　处：《Bioactive Materials》索引2021年第6卷第9期,共14页高影响力期刊 基　　金：The project is supported by the Fundamental Research Funds for the Central Universities(grant No.2232017A-05,2232019A3-06);Science and Technology Support Program of Shanghai(grant No.16441903803,18441902600);the Chinese Universities Scientific Fund(grant No.CUSF-DH-D-2017012)and 111 project(grant No.B07024). 摘　　要：Recent progress in bioresorbable stents(BRSs)has provided a promising alternative for treating coronary artery disease.However,there is still lack of BRSs with satisfied compression and degradation performance for pediatric patients with congenital heart disease,leading to suboptimal therapy effects.Here,we developed a mechanically self-reinforced composite bioresorbable stent(cBRS)for congenital heart disease application.The cBRS consisted of poly(p-dioxanone)monofilaments and polycaprolactone/poly(p-dioxanone)core-shell composite yarns.Interlacing points in cBRS structure were partially bonded,offering the cBRS with significantly higher compression force compared to typical braids and remained good compliance.The suitable degradation profile of the cBRS can possibly preserve vascular remodeling and healing process.In addition,the controllable structural organization provides a method to customize the performance of the cBRS by altering the proportion of different components in the braids.The in vivo results suggested the cBRS supported the vessel wall similar to that of metallic stent.In both abdominal aorta and iliac artery of porcine,cBRS was entirely endothelialized within 1 month and maintained target vessels with good patency in the 12-month follow-up.The in vivo degradation profile of the cBRS is consistent with static degradation results in vitro.It is also demonstrated that there is minimal impact of pulsatile pressure of blood flow and variation of radial force on the degradation rate of the cBRS.Moreover,the lumen of cBRS implanted vessels were enlarged after 6 months,and significantly larger than the vessels implanted with metallic stent in 12 months. 关 键 词：Cardiovascular stent BIORESORBABLE Congenital heart disease Braided technology Thermal treatment
相关文献

参考文献(71)

引证文献(4)

耦合文献(3)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费