Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

查看全文 作　　者：Zhaomeng [1]Cui;Yang [1,2]Liu;Wei [3]Wan;Yuyan [1]Xu;Yehui [4]Hu;Meng [1,2]Ding;Xin [1,2]Dou;Ruina [1]Wang;Hailing [5]Li;Yongmei [6]Meng;Wei [7]Li;Wei [1]Jiang;Zengxia [1]Li;Yiming [8]Li;Minjia [3]Tan;Dengke [9]KMa;Yu [4]Ding;Jun [10]OLiu;Cheng [3]Luo;Biao [7]Yu;Qiqun [1,2]Tang;Yongjun [1]Dang

机构地区：[1]Key Laboratory of Metabolism and Molecular Medicine,The Ministry of Education,Department of Biochemistry and Molecular Biology,Shanghai Medical College,Fudan University,Shanghai 200030,China;[2]Institute of Stem Cell Research and Regenerative Medicine,Institutes of Biomedical Sciences,Fudan University,Shanghai 200030,China;[3]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;[4]Department of Physiology and Biophysics,School of Life Sciences,Fudan University,Shanghai 200438,China;[5]Henan Sesame Research Center,Henan Academy of Agricultural Sciences,Zhengzhou 450002,China;[6]College of Traditional Mongolian Medicine,Inner Mongolia Medical University,Mongolia 010110,China;[7]State Key Laboratory of Bio-organic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;[8]Department of Endocrinology and Metabolism,Huashan Hospital,Fudan University,Shanghai 200040,China;[9]Department of Physiology,Cardiovascular Research Institute,University of California San Francisco,San Francisco,USA;[10]Department of Pharmacology and Molecular Sciences,The Johns Hopkins University School of Medicine,Baltimore,MD,USA

出　　处：《Protein & Cell》索引2021年第12卷第6期,共9页

摘　　要：Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). 关键词：GSTM1 OBESITY ADIPOCYTE

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Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

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