Small molecules in targeted cancer therapy:advances,challenges,and future perspectives

查看全文 作　　者：Lei [1,2]Zhong;Yueshan [1]Li;Liang [1]Xiong;Wenjing [1]Wang;Ming [1]Wu;Ting [2]Yuan;Wei [1]Yang;Chenyu [1]Tian;Zhuang [1]Miao;Tianqi [1]Wang;Shengyong [1]Yang

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu,Sichuan,People's Republic of China;[2]Personalized Drug Therapy Key Laboratory of Sichuan Province,Department of Pharmacy,Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,Sichuan,People’s Republic of China

出　　处：《Signal Transduction and Targeted Therapy》索引2021年第6卷第6期,共48页

基　　金：supported by the National Natural Science Foundation of China(81930125,81702286,81773633,and 21772130);the Research Project of Science and Technology Department of Sichuan Province(2021YJ0134,2019YFS0514,and 2020YFS0006);the 1.3.5 project for disciplines of excellence.West China Hospital,Sichuan University(ZYGD18001);partially by the fast-track grants from West China Hospital,Sichuan University(HX-2019-nCoV-053);the Open Project of Radiation Oncology Key Laboratory of Sichuan Province(2020FSZLX04). 摘　　要：Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,targeted therapeutic drugs have become mainstream cancer treatments.Since the first tyrosine kinase inhibitor imatinib was approved to enter the market by the US Food and Drug Administration(FDA)in 2001,an increasing number of small-molecule targeted drugs have been developed for the treatment of malignancies.By December 2020,89 small-molecule targeted antitumor drugs have been approved by the US FDA and the National Medical Products Administration(NMPA)of China.Despite great progress,small-molecule targeted anti-cancer drugs still face many challenges,such as a low response rate and drug resistance.To better promote the development of targeted anti-cancer drugs,we conducted a comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification.We present all the approved drugs as well as important drug candidates in clinical trials for each target,discuss the current challenges,and provide insights and perspectives for the research and development of anti-cancer drugs. 关键词：DRUGS CHEMOTHERAPY TREATMENT

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Small molecules in targeted cancer therapy:advances,challenges,and future perspectives

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